Ep 585: The Nitric Oxide Fix for Vascular & Sexual Vitality With Dr. Nathan Bryan

In this episode of The Health Fix Podcast, Dr. Jannine Krause sits down with Dr. Nathan Bryan, a leading researcher in nitric oxide (NO) and molecular medicine, to explore how this essential molecule impacts vascular health, chronic disease prevention, sexual health, and aging.

Dr. Bryan explains how nitric oxide is one of the body’s most powerful signaling molecules—regulating blood flow, reducing inflammation, and supporting energy and performance at every age. He shares insights from over two decades of nitric oxide research, including his pioneering discoveries on how NO deficiency contributes to hypertension, inflammation, and sexual dysfunction in both men and women.

They discuss why diet alone isn’t enough to maintain optimal nitric oxide levels in today’s world, how modern agriculture has stripped essential nutrients from our food, and how targeted supplementation and topical applications are helping restore balance and improve health outcomes.

You’ll also hear about the latest breakthroughs in nitric oxide therapy, including clinical results from Bryan Therapeutics, Inc. (BTI) and how innovative NO-based treatments are transforming care for heart disease, Alzheimer’s, and chronic wounds.

Whether you’re interested in longevity, inflammation reduction, sexual health, or simply optimizing your circulation and recovery, this episode reveals why nitric oxide may be the missing link in your wellness strategy.

Resources From The Show:

Dr. Nathan Bryan is an international leader in nitric oxide biochemistry and molecular medicine.
He was the first to identify nitrite and nitrate as indispensable nutrients for cardiovascular health and discovered the endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite.

He has published numerous highly cited scientific papers, authored six books, and led multiple clinical trials validating nitric oxide-based therapies.
Dr. Bryan is also the Founder, Chairman, and CEO of Bryan Therapeutics, Inc., a biotechnology company developing nitric oxide drugs for heart disease, Alzheimer’s, diabetic ulcers, and wound healing.

His consumer nitric oxide products can be found at N1O1.com, NO2U.com, and on Amazon.

---

📚 Learn More About Dr. Bryan:

🔗 Website: https://www.drnathansbryan.com
🔗 Bryan Therapeutics, Inc.: https://www.bryantherapeutics.com
🔗 N1O1 Products: https://www.n1o1.com

---

🎧 Listen to More from The Health Fix Podcast:

Subscribe for weekly conversations exploring the science of longevity, recovery, hormones, and holistic performance — so you can feel strong, focused, and vibrant for life.

📺 Watch all episodes: YouTube.com/@DrJannineKrause
🎙️ Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/the-health-fix-podcast/id1191374534
🎧 Listen on Spotify: https://open.spotify.com/show/0bZOmMXEOQket3GOESHJw4

---

Our Partners

Podcast Transcript

Chapters

00:00 Introduction to Nitric Oxide
01:11 The Role of Nitric Oxide in Chronic Disease
03:19 Nitric Oxide and Acupuncture
05:01 Effects of Nitric Oxide on Heart Rate Variability
06:33 Nitric Oxide in Lyme Disease Treatment
08:07 Nitric Oxide and Sexual Health
10:48 Challenges in Nitric Oxide Supplementation
12:31 Dietary Sources of Nitric Oxide
15:48 Mechanisms of Nitric Oxide Production
18:57 Case Study: Pediatric Patient and Nitric Oxide
22:25 Long-term Impact and Future Research
22:35 The Importance of Nitric Oxide
28:08 Nitric Oxide and Aging
34:34 The Science Behind Nitric Oxide Testing
38:59 Future of Nitric Oxide in Medicine
42:40 Topical vs Oral Nitric Oxide

---

Jannine Krause (00:01.25)
All right, and we’re off. Dr. Nathan Bryan, welcome to the Health Fix Podcast. Thanks, great to be with you. Thanks for having me on. Well, I’m glad that you’re here.

Dr Nathan S Bryan (00:07.096)
Thanks, great to be with you. Thanks for having me on.

Jannine Krause (00:10.964)
have lots of questions about nitric oxide and you fit in some time with a documentary that you’re there to film in in Austin area called Health Secrets. So this is exciting. We’re gonna have to be on the lookout for that. We’ll pop that in the podcast notes. So give us a little background in terms of what do you love so much about nitric oxide? If you had to give me like

Dr Nathan S Bryan (00:24.876)
Sure.

Jannine Krause (00:31.578)
a two second statement maybe, maybe that’s a little short. Let’s give you like a quick statement of like, what is your most favorite thing about nitric oxide?

Dr Nathan S Bryan (00:41.964)
Yes, so my nitric oxide are elevated pitch, right? No, like it’s the most important molecule produced in the human body and the functional loss of nitric oxide is the early stage of the onset progression of age-related chronic disease. So if we can figure out how to restore the natural production of nitric oxide, we can address the onset and progression of chronic disease.

Jannine Krause (00:42.508)
Yes, so my nitric oxide are elevator pitch, right? Yeah. It’s the most important molecule produced in the human body and the functional loss of nitric oxide is the air rates to be at the onset progression of age related chronic disease. So we can figure out how to restore the natural production of nitric oxide. can address the onset of chronic disease. Nice, nice. Well, I always ask that of folks when we’re talking about certain molecules, because I think we I want to kick it off right off to see, you know,

to kind of set the tone. And for when we’re talking about chronic disease, we’re talking about aging, inflammation, that concept for a lot of folks is hot and let’s say relevant, but I don’t think a lot of folks really understand what’s happening when we’re going into the process of inflammation and how nitric oxide ties into the whole aging process.

Dr Nathan S Bryan (01:33.134)
Well, when we look at age-related chronic disease, there’s always four common denominators. There’s always reduced blood flow to the organ. There’s runaway inflammation, as you discussed. There’s oxidative stress. And there’s immune dysfunction. And so what we’re finding is that it’s the loss of nitric oxide that leads to all of this. So nitric oxide is a vasodilator. If we lose the ability to produce nitric oxide, we get constricted blood vessels. We get microvascular dysfunction that leads to ischemia and hypoxia.

Jannine Krause (01:33.807)
But when we look at age-related chronic disease, there’s always four common denominators.

There’s always reduced blood flow to the organ. There’s runaway inflammation that you discussed. There’s oxidative stress and there’s immune dysfunction. And so what we’re finding is that it’s the loss of nitric oxide that leads to all of this. nitric oxide is a vasodilator. If we lose the ability to print nitric oxide, we get conscripted blood vessels. We get microvascular dysfunction that leads to ischemia and hypoxia. We get runaway inflammation. There’s an upregulation of adhesion molecules and lining of blood vessel.

Dr Nathan S Bryan (02:03.31)
We get runaway inflammation. There’s an upregulation of adhesion molecules in lining of the blood vessel. We have oxidative stress. We get an overproduction of NADPH oxidase. The electron transport chain becomes uncoupled and produces superoxide. And then we get immune dysfunction. And to the contrary, if we can restore the natural production of nitric oxide or give nitric oxide, we dilate blood vessels. We inhibit inflammation. We inhibit the oxidative stress.

Jannine Krause (02:08.784)
We have oxidative stress, have overproduction of NADH oxidase. The electron transport chain becomes uncoupled and produces superoxide. And then we get immune dysfunction.

To the contrary, we can restore the natural production of microcoxide or give nitroxide, we dilate blood vessels, we inhibit inflammation, we inhibit the oxidative stress, and we correct the immune dysfunction. So this single molecule of is root cause of chronic disease. It makes sense. And of course, being an acupuncturist myself, I’ve always heard all of my docs and training telling me like circulation, circulation, and even the Chinese clearly knew there was something to the circulation.

Dr Nathan S Bryan (02:32.512)
and we correct the immune dysfunction. So this single molecule addresses the root cause of chronic disease.

Jannine Krause (02:51.264)
nitric oxide as part of it, but they knew there was something to this circulation thing.

Dr Nathan S Bryan (02:56.856)
Well, they call that Qi, right? I mean, it goes back thousands and thousands of years. There’s this gas that animates the human. And we published a paper in 2011 where we described that the Qi that’s been described by thousands of years is actually nitric oxide gas. And so that explains, and you know, things that stand the test of time like acupuncture, you know, they stand the test of time because they’re very effective.

Jannine Krause (03:13.902)
And so that explains, and know, things that stand the test of time like acupuncture, you know, they stand the test of time because they’re very effective.

Absolutely, absolutely. And using acupuncture with nitric oxide, I’ve seen the benefits. And this is something I, you while I don’t do any research in my office, I can definitely say that my mind is looking at all the things and putting them, you know, components together and going like, yes, this is something we need to keep on board. Yes, I see better results with that. Do you guys have acupuncturists that work with you that do provide feedback that folks could look at? Do you have some white papers or articles or whatnot in that case?

We don’t have any since your question. Yes, we have a number of different health care practitioners from acupuncturists chiropractors medical doctors Eos mean it spans the spectrum of practitioners and so we’ve done randomized placebo-controlled clinical trials

Dr Nathan S Bryan (03:52.514)
We don’t have any, since you question us, have a number of different healthcare practitioners from acupuncturists, chiropractors, medical doctors, DOs, mean, it spans the spectrum of practitioners. And so we’ve done randomized placebo-controlled clinical trials and looking at clinically relevant endpoints, but we never have really done a controlled clinical study in acupuncture.

Jannine Krause (04:08.684)
and looking at clinically relevant endpoints, we never have really kind of controlled clinical study in acupuncture. It would be interesting to see what’s irrelevant, and I don’t know enough about it to a relevant endpoint we could capture. Yeah. Publish an opinion or even create a white paper. I would wonder if, by any chance, like going back to the nervous system, going back to cardiovascular system, if a monitor of HRV in the moment, since we can monitor HRV, you know, watching in like a workout

Dr Nathan S Bryan (04:15.96)
going to be interesting to see what’s irrelevant and I don’t know enough about it to what’s a relevant endpoint we could capture and publish in a paper or even create a white paper.

Jannine Krause (04:38.618)
that with a particular watch, I wonder if by any chance having them with a watch on HRV and then pre and post checks with the nitric oxide on board. I don’t know, we might be creating a research study. No, for sure. No, we have that. We’ve used HRV as a measurement and an endpoint, not really primary endpoint, but secondary endpoints in clinical studies. Nitric oxide has a really profound effect on HRV.

Dr Nathan S Bryan (04:50.7)
No, for sure. No, we have that. We’ve used HRV as a measurement and an endpoint. Not really primary endpoint, but secondary endpoints in clinical studies. Nitric oxide has a really profound effect on HRV.

Jannine Krause (05:03.714)
You know, I’d like that you mention that about the HRV in particular, because I think it’s one of, even though it’s not a primary, as you say, like, endpoint, it is something that a lot of people are coming to look at and realizing, like, okay, I need to look at this, I need to see the long game on it, what’s happening. Tell us a little more about what you have seen with the use of nitric oxide over time and adjustments with HRV. Well, we know if we deliver nitric oxide, we can dilate blood vessels, we can normalize blood pressure.

Dr Nathan S Bryan (05:27.822)
Well, we know if we deliver nitric oxide, we can dilate blood vessels, we can normalize blood pressure in hypertensive patients or patients with an elevation in blood pressure. If you have normal or low blood pressure, there’s no blood pressure lowering effect, which is very important. We know we can reduce inflammation, in fact, have a number of patents on the method of reducing inflammation.

Jannine Krause (05:33.647)
in hypertensive patients or patients with an elevation of blood pressure. If you have normal or low blood pressure, there’s no blood pressure lowering effect, which is very important. We know we can reduce inflammation. In fact, I have a number of patents on the method of reducing inflammation. We can normalize triglycerides. Patients have a triglycerides rate of 150, we see about a 27 % reduction in 30 days. Again, if you patent on correcting hyperfibidemia.

Dr Nathan S Bryan (05:48.728)
We can normalize triglycerides. Patients have a triglycerides rate of 150. We see about a 27 % reduction in 30 days. Again, if you patent on correcting hyperhepidemia. What else? We see a mobilization of stem cells. We see an improvement in vascular function, but a 20 % improvement in the female function within 20 minutes of taking my lozenge. Peripheral neuropathy.

Jannine Krause (06:01.806)
What else? see a mobilization of stem cells. Nice. We see an improvement in vascular function, a 20 % improvement in the tibial function. And 20 minutes of taking my lozenge. Peripheral neuropathy.

Dr Nathan S Bryan (06:17.784)
What else? Remediation of kidney disease. We stopped spilling protein in the urine. In one clinical pediatric case, we saw a resolution of heart disease within five months. We see about 11 % black regression in the carotid arteries after six months. That’s just a small list we’ve been able to demonstrate.

Jannine Krause (06:18.062)
What else? Remediation of kidney disease. stopped spilling protein in the urine. In one clinical pediatric case, we saw resolution of heart disease within five months. We see about 11 % black regression in the carotid arteries after six months. Wow.

You know, right, right. mean, I’ve seen, mean, I’ve seen all kinds of different things and, turning, turning around. And one of our big things here at the practice up in Wisconsin is we work with a lot of Lyme patients and see a lot of neuropathy from Lyme. And so I, you know, look at it as one of our adjunct tools to kind of help along with the process. What have you seen personally in your research looking at Lyme in particular?

Dr Nathan S Bryan (07:03.138)
Well, it’s a complicated disease. A lot of times it’s under diagnosed or misdiagnosed. But with any disease, there’s always a vascular component. And people who have poor circulation are typically more susceptible to not only Lyme infections, but other pathogens. Because poorly vascularized tissues are more susceptible to infections. And part of our innate immune system is going to that site of infection.

Jannine Krause (07:03.47)
Well, it’s a complicated disease. A lot of times it’s under diagnosed or misdiagnosed.

But with any disease, there’s always a vascular component. And people who have poor circulation are typically more susceptible to not only Lyme infections, but other pathogens. This poorly vascularized tissue is more susceptible to infections. And part of our innate immune system is going to that side of the infection. Our macrophages and it feels produced a lot of hydroxide. It’s a bacterium. It binds to the iron sulfur spinous. The bacteria shuts down the respiration. it’s virus, prevents the virus from replicating.

Dr Nathan S Bryan (07:26.114)
macrophages and it feels produced a lot of micrococci and if it’s a bacterium it binds to the iron sulfur centers, the bacteria shuts down their respiration. If it’s a virus it prevents the virus from replicating. But if that person is you know has vascular complications or can elicit an immune response then they becomes susceptible to those infections. So that kind of explains the risk of certain patients get Lyme or other infections. But I think the remediation process, micrococci can certainly help.

Jannine Krause (07:38.924)
has vascular complications or inelicited immune response, then it becomes susceptible to those infections. So that kind of explains the risk of certain patients get Lyme or other infections. But I think the remediation process, I could talk to them about, because we’re gonna fully oxygenate that tissue, we’re gonna dilate the blood vessel, we’re gonna root capillaries, we’re gonna activate an immune response, and we’re gonna help with the detox, healing the pathogen and eliminating the toxic metabolic byproducts of those infections.

Dr Nathan S Bryan (07:54.286)
because we’re going to fully oxygenate that tissue, we’re going to dilate the blood vessel, we’re going to recruit capillaries, we’re going to activate an immune response, and we’re going to help with the detox, healing the pathogen and eliminating the toxic metabolic byproducts of those infections.

Jannine Krause (08:08.942)
I mean, it makes perfect sense. It makes perfect sense to have it as part of the whole protocol. And this is something that we do look at here as well. Another thing that I kind of gave you a little pre-knowledge on this one that I was gonna ask this one, but you know, I also in my Washington state practice see a lot of women for hormone issues. And one of the big things that of course we see with circulation of blood flow, you know, with men we’ve got erectile dysfunction. With women, we also do have erectile dysfunction that

Dr Nathan S Bryan (08:29.934)
See

Jannine Krause (08:39.136)
we’re not really talking about the circulation to the clitoris. We’re not talking about circulation even to the labia and you know with the skincare products where like your serums that you have the nitric oxide I’m going why are we not talking about this for the vaginal tissue? What’s going on here?

Dr Nathan S Bryan (08:53.358)
There you go. Yeah. Well, look, when you reach andropause, whether it’s in men or women, we lose the natural production of testosterone in men and estrogen in women. And that causes a lot of symptoms, EV in men and hot flashes and things like that in women. So what we’re finding is it’s not just enough to restore the hormones, testosterone or estrogen.

Jannine Krause (08:56.92)
Well, look, when you reach andropause, whether it’s in men or women, we lose the natural production of testosterone in men and estrogen in women. And that causes a lot of symptoms, ED in men and hot flashes and things like that in women. So what we’re finding is it’s not just enough to restore the hormones, testosterone or estrogen. We have to restore the natural production of nitric oxide in order to gain the cardio-protective benefits of hormone replacement therapy.

Dr Nathan S Bryan (09:16.61)
we have to restore the natural production of nitric oxide in order to gain the cardio protective benefits of hormone replacement therapy. Because if you just give hormone replacement therapy that don’t fix the enzyme in the lining of blood vessels, a lot of times you don’t improve sexual dysfunction in men and women. So in men, obviously to get in right direction, we have to dilate the blood vessels of the sex organs. And that dilation comes from the production of nitric oxide.

Jannine Krause (09:24.654)
Because if you just give hormone replacement therapy that don’t fix the enzyme in the lining of the udder muscles, a lot of times you don’t improve sexual dysfunction in men and women. So in men, obviously, to get it right, we have to dilate the blood vessels of the sex organs. And that dilation comes from the production of nitric oxide. So erectile dysfunction is a symptom of nitric oxide deficiency. And then in women, what we want to is not just libido and arousal.

Dr Nathan S Bryan (09:42.478)
So erectile dysfunction is a symptom of nitric oxide deficiency. And then in women, what we look at is not just libido and arousal, but orgasm. When we look at the hemodynamic effects of orgasm in women, you mentioned that you have to have an increase in pressure, clitoral pressure, labial pressure. So that pressure comes from an increase in volume. That volume comes from dilated ligatins. And that dilation comes from nitric oxide.

Jannine Krause (09:52.111)
that orgasm, when you look at the hemodynamic effects of orgasm in women, you mentioned that you have to have an increase in pressure, literal pressure, labial pressure, so that pressure comes from an increase in volume. That volume comes from dilated ligaments. And that dilation comes from nitric oxide. So if you can’t make nitric oxide in the vasculin of the sex organs, women become at orgasm, they lose libido. And then to the contrary, if we can restore the production of nitric oxide,

Dr Nathan S Bryan (10:09.398)
So if you can’t make nitric oxide in the vasculature of the sex organs, women become an orgasmic, they lose libido. And then to the contrary, if we can restore the production of nitric oxide, they get better sensation, enhanced libido, better orgasms. So again, female sexual arousal disorder is a symptom of nitric oxide deficiency.

Jannine Krause (10:20.856)
get better sensation, the fetal, better orgasms. So again, female sexual arousal disorder is a symptom of nitric oxide deficiency. Makes sense, makes sense. I tend to look of course, and a lot of women are gonna be like, nitric oxide serums. And I’ve seen different iterations over the course of time for different companies and then I’ve seen them go away. And so I’m very curious about with putting nitric oxide boosting components into a serum, what kind of challenges do you run?

up to, how can you maximize increased absorption on the skin and what kind of things have you discovered in the research to create your serum products?

Dr Nathan S Bryan (11:01.102)
Well look, there a lot of these fly-by-night companies that come and go and try to create nitric oxide products and they go out of business because their products don’t work and their products don’t work because they don’t understand the science. And so, you I spent 25 years in academia as a professor of molecular medicine really understanding how the human body makes nitric oxide, what leads to its natural production. And so that gives me a unique set of skills to create product technology that stores and recapitulates nitric oxide production in significant ways.

Jannine Krause (11:01.454)
There are a of these fly-by-night companies that come and go and try to create nitric oxide products and they go out of business because their products don’t work. And their products don’t work because they don’t understand the science. And so, you I spent 25 years in academia as a professor of molecular medicine really understanding how the human body makes nitric oxide, what leads to its natural production. And so that gives me a unique set of skills to create product technology that stores and recapitulates nitric oxide production in supermarkets.

Dr Nathan S Bryan (11:29.516)
So our whole goal, going back 25 years ago, was how do we restore the natural production of nitric oxide and give nitric oxide at doses that are not fluid. So when we do that, we’re basically, there are no challenges because we’re mimicking what the body would naturally do. So we an orally disintegrating tablet that produces nitric oxide gas in the oral cavity. And if you mentioned, we make a dual chamber nitric oxide serum, because I think it’s important to your listeners, nitric oxide’s a gas.

Jannine Krause (11:29.772)
So our whole goal, going back 25 years ago, was how do we restore the natural production of nitric oxide and give nitric oxide at doses that are not completely neutralized? So when we do that, we’re basically, there are no challenges because we’re mimicking what the body would naturally do.

So we have an orally disintegrating tablet that produces hydroxide gas in the neural cavity. And if you mentioned, we make a dual chamber hydroxide theorem. Because I think it’s important to go through hydrocoxides of gas.

Dr Nathan S Bryan (11:59.726)
It’s not a pill you can swallow. It’s not something you can just take and hope your body makes it. That’s the basis for the deficiencies. So our dual chamber, we have to keep these components separate. We mix them together, they come together and generate nitrocoxide gas.

Jannine Krause (11:59.919)
It’s not a pill you can swallow. It’s not something you can just take and hope your body makes it. That’s basis for the deficiencies. So our dual chamber, have to these components separate. We mix them together. They come together in different microfiber gans. And then when you apply it to the face or any tissue, it’s going to fuse into the tissue. It’s going to dilate the blood vessels. And you can actually see it working. The skin’s going to turn pink because it’s causing a hyperemic response.

Dr Nathan S Bryan (12:14.862)
Then when you apply it to the face or any tissue, it’s going to fuse into the tissue, it’s going to dilate the blood vessels. And you can actually see it working. The skin’s going to turn pink because it’s causing a hyperemic response. We’re fully oxygenating the tissue, we’re dilating blood vessels and restoring normal vasculature function.

Jannine Krause (12:27.246)
fully oxygenating the teeth, we’re dilating blood vessels and restoring normal vasculature.

I think that’s really important to explain and because I kind of jumped past that side of things because unfortunately that’s sometimes the problem of being a practitioner and thinking, doesn’t everybody know that? Let’s talk about that for a second because we’re told food is medicine and people are, and I’ve talked to folks about trying to get more beets and trying to get more arugula, trying to get more spinach, but the amount of that that we would have to eat to boost nitric oxide production in the body is no one’s going to eat that much.

Dr Nathan S Bryan (12:43.374)
That’s

Jannine Krause (13:03.338)
And so I would love for you to kind of explain the whole detail of how you actually get nitric oxide production from even the beet powders and things of that nature.

Dr Nathan S Bryan (13:13.262)
Yeah. Well, unfortunately, beets are probably the poorest source of nitric oxide. And so a lot of times the companies with the most expensive marketing budget have the least efficacious products. So we don’t believe the TV commercials that you’re seeing because they just simply don’t understand the science. But there is a mechanism that consumers in your list understand that you can get nitric oxide from things like arugula beans from your diet. But we know that we need at least 300 to 400 milligrams.

Jannine Krause (13:14.478)
Well, unfortunately, beets are probably the poorest source of nitric oxide. And so a lot of times the companies with the most expensive marketing budget have the least efficacious products. So we don’t believe the TV commercials that you’re seeing because they just simply don’t understand the science. But there is a mechanism that consumers in your list here can understand that you can get nitric oxide from things like arugula beans from your diet. But we know that we need at least 300 to 400 milligrams in a single bowl.

Dr Nathan S Bryan (13:42.766)
in a single bowl. And in 2015, we published a paper really trying to answer that question, what’s arugula or spinach or celery or broccoli what I need to eat to get that 300, 400 milligrams to produce nitric oxide to normalize your blood pressure or to improve blood flow. And what we revealed was that depends on where you live and what vegetables you need. So if you lived in Dallas or Los Angeles,

Jannine Krause (13:44.385)
And in 2015 we published a paper really trying to answer that question, what’s arugula or spinach or celery are probably what I need to eat to get that 300, 400 milligrams to produce nitroxide to normalize your blood pressure or to improve blood flow. And what we revealed was that it depends on where you live and what vegetables you need.

So if you lived in Dallas or Los Angeles, you could eat five stalks of celery, get enough nitrate, lower your blood pressure. If you lived in New York, you’d have to eat 30, 40 stalks of celery. So there’s regional differences in the nitrate and nutrient intensity of the foods we’re eating. So it’s impossible to predict or know. The other major kind of hurdle is that nitrate is inert in humans.

Dr Nathan S Bryan (14:09.57)
can eat five stalks of celery, get enough nitrate to lower your blood pressure. If you lived in New York, you’d have to eat 30 40 stalks of celery. So there’s regional differences in the nitrate and nutrient density of the foods we’re eating. So it’s impossible to predict or know. The other major kind of hurdle is that nitrate is in urban humans. So if you’re consuming these vegetables and you don’t have the right oral bacteria,

Jannine Krause (14:35.36)
So if you’re consuming these vegetables and you don’t have the right oral bacteria, just scrape the nitrate in your urine, in your feces, and in your sweat. And so with two out of three Americans using mouthwash, with nine out of 10, probably 99 out of 100 people using fluoride in their toothpaste, and then some of the US have fluoride in their drinking water.

Dr Nathan S Bryan (14:39.022)
You just excrete the nitrate in your urine, in your feces, and in your sweat. And so with two out of three Americans using mouthwash, with nine out of 10, probably 99 out of 100 people using fluoride in their toothpaste, and then 73 % of the municipalities in the US have fluoride in their drinking water, they’re killing the bacteria. So you’re not gonna get any clinical benefit from swallowing a nitrate capsule, like many companies are selling.

Jannine Krause (14:59.022)
they’re killing the bacteria. So you’re not going to get any clinical benefit from following a nitrate capsule, like many companies are selling, or trying to eat beets or arugula or spinach. So that’s number two. Then number three, we need stomach acid in order to finish this process. And 200 million prescription franacids every year, 230 million people using over-the-counter.

Dr Nathan S Bryan (15:08.014)
or trying to eat beets or arugula or spinach. So that’s number two. Then number three, we need stomach acid in order to finish this process. And 200 million prescriptions for antacids every year. Two out of three Americans are using over-the-counter antacids, and it’s completely disrupting mycococcal production. And if you look at the clinical data on PPI use, it’s causing a 40 % increase in heart attacks, and Alzheimer’s. So.

Jannine Krause (15:24.398)
and acids and it’s completely disrupting nitric oxide production and if you look at the clinical data on PPI use it’s probably a 40 % increase in heart attacks, broken heart, Alzheimer’s. So the point here is it’s very difficult to get nitric oxide from your diet because of the oral hydronic practices, because of pharmacotherapy. So we’re almost forced to supplement with a product that actually produces nitric oxide for you.

Dr Nathan S Bryan (15:35.5)
The point here is it’s very difficult to get nitric oxide from your diet because of the oral hygienic practices, because of pharmacotherapy. So we’re almost forced to supplement with a product that actually produces nitric oxide for you.

Jannine Krause (15:50.169)
That makes sense. That makes sense. I would love to hear you kind of explain folks to folks how a product actually helps you produce the nitric oxide because you know, we can imagine these things, but because of your scientific nature and background and studying this, you’re going to explain it so much better than me. So I’m really personally going to probably clip this part so I can repeat, like repeat it to people because my explanation just always gets in the weeds. So please help us.

Dr Nathan S Bryan (16:18.318)
Well, look, there’s two ways the human body makes nitric oxide. There’s an enzyme in the lining of the blood vessels called nitric oxide synthase, and this enzyme takes L-arginine, which is a semiocetral amino acid, and through a very complex five-electron oxidation reaction produces nitric oxide gas. Then we get L-citrulline as a byproduct. So the problem is the older we get, the less functional that enzyme becomes, and we call that endothelial dysfunction.

Jannine Krause (16:18.99)
There’s two ways that human body makes nitric acid. There’s an enzyme in the lining of the blood vessels called nitrocoxides synthase. And this enzyme takes L-arginine, is a semi-acetyl amino acid, into a very complex five electron oxidation reaction that produces nitrocoxides. Then we get L-citrate as a byproduct. So the problem is the older we get, the less functional that enzyme becomes. We call that endothelial dysfunction.

Dr Nathan S Bryan (16:47.554)
We’ve lost the ability to utilize arginine to make nitric oxide. But we’re never out of arginine. So it makes no sense to take the supplement arginine. Because that would be like putting gas in a car with a blown up engine. Your problem is not you’re out of fuel. You’ve lost the ability to utilize that. So that’s number one. Then number two, we talk about this redundant pathway of using nitrate for the diet. But we’ve talked about the limitations of that.

Jannine Krause (16:48.258)
We’ve lost the ability to utilize arginine to make micro-oxide. But we’re never out of arginine. So it makes no sense to take the supplement arginine. Because that would be like putting gas in a car with a blow in the engine.

Problem is not you’re out of fuel you’ve lost the ability to utilize that So this number one and number two we talked about this this redundant pathway of using nitrate from the diet But we talked about the limitations of them. So all the deep products on the market don’t provide any Nitric oxide benefit because of the things we discussed and furthermore most of the products on the markets believe in any detectable Nitrate or nitrate in them. So these are what we call dead deeps

Dr Nathan S Bryan (17:15.734)
So all the beet products on the market don’t provide any nitric oxide benefit because of the things we discussed. And furthermore, most of the beet products on the markets don’t even have any detectable nitrate or nitro in them. So these are what we call dead beets. We use them as placebo in our clinical trial. And then some people are telling you to take these capsules of beet powder and they just don’t understand the method.

Jannine Krause (17:33.473)
And some people are telling you to take these capsules of beet powder and they just don’t understand the matter. Because even if you had a concentrated beet powder, say, you know, three to five percent concentrated in nitrate, you would have to consume 3,000 to 5,000 milligrams, or three to six grams, and yet you only get 700 milligrams on a capsule.

Dr Nathan S Bryan (17:42.158)
Because even if you had a concentrated beet powder, say, you know, 3 to 5 % concentrated in nitrate, you would have to consume 3,000 to 5,000 milligrams, or 3 6 grams, and yet you only get 700 milligrams in a capsule. So these companies telling you to three capsules of this beet powder, I mean, it’s ludicrous. And it would be humorous if it wasn’t dangerous, because it’s disingenuous.

Jannine Krause (18:00.11)
So these companies telling you three capsules of this beet powder, I it’s ludicrous. And it would be humorous if it wasn’t dangerous. Because it’s disingenuous. And then they’re putting a little bit of beet in a gummy or a chew and telling you it’s not condense. I mean, the numbers don’t work.

Dr Nathan S Bryan (18:10.06)
and then they’re putting a little bit of bead in a gummy or a chew and telling it’s nitric oxide. I mean, the numbers don’t work because these companies don’t understand the science. They’re out there trying to take advantage of a growing market, expanding market, and they’re interested in making money and finding the cheapest product they can, but it doesn’t work. It can’t work.

Jannine Krause (18:18.284)
Because these companies don’t understand the something. They’re out there trying to take advantage of a growing market, standing market, and they’re interested in making money on the cheapest product they can. It doesn’t work. It can’t work. This is such a problem in the natural medicine space. And it’s one of them that, you know, it makes…

It’s made me kind of getting frustrated with what do I recommend? How do I do this? How do I know, you know, and this is when I like to use the podcast to be able to interview folks like you, because now I have a face, a name, and you know, I can troubleshoot better there. Now, in terms of some of the surprising things that you’ve seen about nitric oxide, I would love to hear like even your own story, any like wild, like you’re like, wow, I did not expect it to help with this or that. Let’s talk about those kind of fun things.

Dr Nathan S Bryan (19:01.006)
We have.

Dr Nathan S Bryan (19:12.814)
Well, I always talk about the study we published in 2011 in a pediatric patient, a 15-year-old kid at Texas Children’s Hospital who was born with a very rare genetic disorder. And for 10 years, he suffered from severe hypertension, what we call resistant hypertension. He was put on four different medications, and he presented to Texas Children’s Hospital in the pediatric intensive care unit in 2010. And his blood pressure was 210 over 115.

Jannine Krause (19:13.134)
Well, I always talk about the study we published in 2011 in a pediatric patient, a 15-year-old kid in Texas Children’s Hospital. He was born with a very rare genetic disorder, and for 10 years he suffered from severe hypertension. It was called resistant hypertension. He was put on four different medications.

And he presented to Texas Children’s Hospital in the pediatric intensive care unit in 2010. And his blood pressure was 210 over 150. So this was a critical situation for this kid. He was at risk for stroke.

Dr Nathan S Bryan (19:39.33)
So this was a critical situation for this kid. was at risk for stroking. And so we had understood this when we modeled this in the research lab, that it was a symptom of nitric oxide deficiency. And so we dosed this kid with our nitric oxide releasing lozenge. Within four hours, his blood pressure came down to 130 or 80. And this was remarkable because I had eight different physicians in the room with me from a geneticist, a pediatric cardiologist, a nephrologist.

Jannine Krause (19:46.063)
And so we had understood this when modeled this in the expert lab, that was a symptom of nitric oxide deficiency. And so we dosed this kid with our nitric oxide releasing lozenge, and four hours his blood pressure came down to 130 degrees. And this was remarkable because I had different physicians in the room with me from a geneticist, a pediatric cardiologist, a neurologist, a police specialist.

Dr Nathan S Bryan (20:08.978)
specialist and we watched in real time the blood pressure come down. We didn’t change this kid’s genetics, he still had the inborn air metabolism, but just giving nitric oxide to dilate the blood vessels normalizes blood pressure, getting rid of the pediatric intensive care unit. And then furthermore within five days his kidney disease resolved. He was no longer spilling protein in the urine and within five months it completely resolved his heart disease. This 15 year old kid had a heart twice the size of a normal 15 year old.

Jannine Krause (20:11.084)
And we watched in real time the blood pressure come down. We didn’t change this genetic, we still had the inborn air metabolism. But just giving nitrocoxides dilates the blood vessels, normalizes blood pressure, getting that to the pediatric intensive care unit. And then furthermore, within five days, his kidney disease was resolved. He was no longer spilling protein in the urine. And within five months, it completely resolved his heart disease.

This 15 year old kid had a heart twice the size of a normal 15 year old. Within five months he had a heart size and normal heart condition. And his cognition improved. He started beating his dad to death. We published that in the American Journal of Humanities in 2011. To me that was the most remarkable, really profound impact we had on this kid because the doctors were really at the ball. had nothing else to treat him with.

Dr Nathan S Bryan (20:38.35)
Within five months, had normal heart size and normal heart function. And his cognition improved. He started beating his dad in tests. We published that in the American Journal of Human Genetics in 2011. to me, that was the most remarkable, really profound impact we had on this kid because the doctors were really at a bull’s They had nothing else to treat him with.

Jannine Krause (21:01.196)
Wow. So who thought of it? Were you involved in the case in the first place? It sounds like you were there. Were you involved? I was involved. know, clinicians at Children’s Hospital approached me when I was at UT Medical School in Houston, the Institute of Molecular Medicine. And really the beauty of the Texas Medical Center is you get clinicians who collaborate with basic doctors to try to understand of complex medical cases. And in this case, they couldn’t understand these collateral symptoms based on this diagnosis.

Dr Nathan S Bryan (21:08.45)
I was involved. know, the clinicians at Tepkin Children’s Hospital approached me when I was at UT Medical School in Houston at the Institute of Molecular Medicine. And really the beauty of the Texas Medical Center is you get clinicians who collaborate with basic scientists to try to understand of complex medical cases. And in this case, they couldn’t understand these collateral symptoms based on this diagnosis. So they brought me into the mix to try to help them understand these collateral symptoms.

Jannine Krause (21:31.023)
So they brought me into the mix to help them understand these collateral symptoms. And then obviously we figured it out and we published a very important paper in Naked Medicine in 2010 where we solved the riddle of this condition. And then once we understood mechanistically what was going on, then and only then we started to develop rational therapies for them.

Dr Nathan S Bryan (21:35.502)
And then obviously we figured it out and we published a very important paper in Nature Medicine in 2010 where we solved the riddle of this condition. And then once we understood mechanistically what was going on, then and only then we started to develop rational therapies for them. So it was a team effort.

Jannine Krause (21:50.831)
So was a team effort. Yeah, yeah, I would love to see. I would love to see this, you know, across the board. It would be so fabulous. Now, have you heard from this kiddo? Do you know what happened since we’re now 10 plus years past that date? Now, I still keep in touch with him and his family. PBS came to the medical center and did a special one was called Healing Quest. You know, we talked about his mother started crying, it saved her son’s life.

Dr Nathan S Bryan (22:05.836)
Now I still keep touch with him and his family. PBS came to the medical center and did a special on us called Healing Quest. You know, we talked about his mother, started crying because he said this saved her son’s life. You know, it allowed us to go to the National Institute of Health and we got, you know, billions of dollars in funding to further investigate this in this rare genetic disorder. But yeah, I’ve…

Jannine Krause (22:19.854)
know, it allowed us to to the National Institute of Health and we got, you know, millions of dollars in funding to further investigate this rare genetic disorder.

Dr Nathan S Bryan (22:30.862)
We’ll keep in touch with them. The physicians at Texas Children’s Hospital still see them periodically just as checkups, it continues to take our product technology, and that’s the only thing that’s managing this blood pressure and keeping it healthy.

Jannine Krause (22:40.809)
Wow, I was gonna ask is he still does he still have to take it? mean that that’s a great Yeah, this is a great segue because yes, you know We we’ve I’ve seen the data where you know We decline on nitric oxide production and I’ve seen the exponential data like over 40 or whatnot, but my curiosity is

Dr Nathan S Bryan (22:46.808)
He has to take a minute.

Jannine Krause (23:00.184)
is I think a lot of people, with supplements in particular, because we’re so used to medications, we take a medication for a timeframe and then we’re off, or do I need this for life? How does it work? What do you personally recommend if someone’s just, everyday Joe, doesn’t have a blood pressure issue, someone who just wants to help optimize?

Dr Nathan S Bryan (23:22.734)
Yeah, I tell people there’s only two people in the world who need nitric oxide. There’s the sick who want to get well, and then there’s the healthy who don’t want to get sick. So if you follow within one of those two, it’s a good idea to be proactive and take it prophylactically. You know, for me personally, I’ve been taking it. When I first made these discoveries probably 20 years ago, this nitric oxide, I take it not because I need it, because I don’t want to need it. But what we understand about physiology and medicine is that

Jannine Krause (23:28.696)
And then there’s the healthy who don’t make it sick. So if you fall within one of those two, it’s a good idea to be proactive and take it prophylactically. You for me personally, I’ve been taking it. When I first made these discoveries probably 20 years ago, this nitro toxin, I take it not because I need it, because I don’t want to need it. But what we understand about physiology and medicine is that if the food you eat is replete in nutrients and you’re not exposed to the outside toxins,

Dr Nathan S Bryan (23:51.534)
If the food you eat is replete in nutrients and you’re not exposed to the outside toxins, then you give the body what it needs to body heal itself. But the problem is, since the 1940s, there’s been surveys since the 1940s, the food grown in America has 76 % less nutrients in 2010 than it did in the 1940s. So the point is, the food that we eat is nutrient depleted.

Jannine Krause (23:58.159)
then you give the body what it needs to help itself. But the problem is, since the 1940s, have been surveys since the 1940s, the food grown in America has 76 % less nutrients in 2010 than it did in the 1940s. So the point is, the food that we eat is nutrient depleted. And then you’ve got herbicides, pesticides, you’ve got environmental toxicants.

Dr Nathan S Bryan (24:18.766)
And then you’ve got herbicides, pesticides, you’ve got environmental toxicants, you’ve got 5G that creates a frequency that’s disrupting a lot of biochemistry and enzymatic reactions, including nitroxide production. And so you almost have to take a daily nitric oxide just to dilate the blood vessels, the inflammation at bay, and to maintain optimal circulation.

Jannine Krause (24:23.95)
You’ve got 5G that creates a frequency that’s disrupted a lot of biochemistry and informatic reactions, including nitric oxide production. And so you almost have to take a daily nitric oxide just to dilate the blood vessels, take the inflammation a day, and to maintain optimal circulation.

It makes sense. It makes sense. And if you look at the trajectory of aging, and now I’ve been in the practice long enough where I’ve started to see folks who had normal blood pressure, it starts to go up with age. And then we have folks like my dad who’s going to be 90, you know, and he’s had a quadruple bypass, all these different things. And he’s asking, you know, what can I do because he doesn’t feel great on the blood pressure meds. And many people have a cough, many people will try multiple and nothing seems to work. This seems to be okay, something to

logistically think about when that’s not happening. Look, we know 50 % of the patients that are given anti-hypertensive medications don’t respond with an improvement in lip-reading. I that’s indisputable clinical. And when we look at the class of medications used to treat hypertension,

Dr Nathan S Bryan (25:15.926)
Yeah. Look, we 50 % of the patients that are given anti-hypertensive medications don’t respond with an improvement in blood pressure. mean, that’s indisputable clinical data. And when we look at the class of medications used to stream hypertension, their ACE inhibitors, is called angiotensin converting enzyme inhibitors. There’s ARBs, angiotensin receptor blockers, calcium channel blockers, or really bad docs will give patients beta blockers, sometimes diuretic to just unload the volume.

Jannine Krause (25:31.631)
their asin hypnosis, which is called angiotensin converting enzyme hypnosis. There’s ARBs, angiotensin receptor blockers, calcium channel blockers, or really bad dogs who get patients’ beta blockers, sometimes diuretics just unload the volume. And so what we’re finding is that these drugs don’t work because their hypertension is not due to renal angiotensin. It’s not due to calcium dysregulation. It’s due to nitric oxide deficiency.

Dr Nathan S Bryan (25:46.542)
And so what we’re finding is that these drugs don’t work because their hypertension is not due to renal angiotensin. It’s not due to the calcium dysregulation. It’s due to nitric oxide deficiency. So if we give nitric oxide, we dilate the blood vessels. And what I say is nitric oxide fixes the physics problem of hypertension. Because we all have a finite amount of blood pumping through the pipes. And if we lose nitric oxide,

Jannine Krause (26:00.398)
So if we give nitric oxide, we dilate the blood vessels. What I say is nitric oxide fixes the physics problem of hypertension. Because we all have a finite amount blood pumping through the pipes. And if we lose nitric oxide, we have smaller blood vessels, smaller pipes, increased resistance. And if you remember back from your high school physics, pressure equals volume times resistance. So the volume stays the same. Resistance goes up because of constriction. Pressure goes up.

Dr Nathan S Bryan (26:14.434)
we have smaller blood vessels, smaller pipes, increased resistance. And if you remember back from your high school physics, pressure equals volume times resistance. So the volume stays the same, resistance goes up because of constriction, pressure goes up. So now the same volume, we decrease resistance by dilating the blood vessels, pressure comes down. And it’s really that simple. So then you have to ask yourself, or ask the patient, why are you nitro-coxed like a patient? You use fluoride in your toothpicks, or are you using mouthwash?

Jannine Krause (26:29.826)
Now the same volume would decrease resistance by dilating the blood vessels, pressure comes down. And it’s really that simple. So then you have to ask yourself, as a patient, why are you nitro-coxed? You use fluoride in your toothpicks. Are you using mouthwash? Are you taking in acids? When you address those three things, you bring them back 30 days later, the blood pressure is normal, and now you can wean them off the patient. Thanks.

Dr Nathan S Bryan (26:43.884)
Are you taking in acids? When you address those three things, you bring them back 30 days later, the blood pressure is normal, and now you can wean them off prescription medications.

Jannine Krause (26:55.244)
Makes perfect sense. Makes perfect sense. I’m glad you outlined that of things to look at that helps folks to really kind of nail it down and go, okay. So. No, no it’s not. And I don’t think that I would have really understood it because I can, if I look back at my training, granted it’s been a few years since I was in school, but I don’t remember other than in physics

Dr Nathan S Bryan (27:03.788)
Yeah, it’s been really obvious. It’s been obvious to me for 20 years, but yet most clinicians don’t understand this because it’s not part of their therapeutic armament.

Jannine Krause (27:25.168)
talking about nitric oxide, but not using it as much. And granted, I’m a naturopath, so we talked about herbs and we talked about boosting circulation. And really drivers, so things like ginkgo and things like, you know, tianhuai and different herbs. I’m like, well, I could see how those would be a great adjunct to using nitric oxide supportive therapies.

Dr Nathan S Bryan (27:47.352)
For sure, you know it’s a huge problem. I taught in medical school for number of years and it’s not part of the curriculum. You I taught a course called the molecular basis of cell signaling, but it really only the MDP students. We talked about nitric oxide and signal transduction and activation of second messenger systems, but the general medical school clients doesn’t get this education. And yet, so if they’re not taught it, how can they use it in diagnosis and treatment?

Jannine Krause (27:51.789)
And it’s not part of the curriculum. I taught a course called the molecular basis of cell signaling. It was really only the MDP students. We talked about nitric oxide and signal transduction and activation of second messenger systems. But the general medical school clients doesn’t get this education. And yet, so if they’re not taught it, how can they use it in diagnosis and treatment?

No, that’s I mean a lot of of what I’ve had to learn is is on my own after school and having the podcast I mean I do this. Yes guys just as much for me as for you because it helps me to really understand You know what’s going on here now, of course I get asked a lot Back to I mentioned before about skincare and you know Can we kind of ditch the Botox and all the things if we use?

Dr Nathan S Bryan (28:26.537)
That’s true.

Jannine Krause (28:44.588)
nitric oxide instead because we’ve you we’re working on our natural abilities to to enhance skin and then I also will get the the question about hyperpigmentation. So all the dark spots all of like the the liver spots. Have you guys done any research on seeing if that’ll reduce liver spot production over time in the damaged tissue?

Dr Nathan S Bryan (28:59.374)
Yeah.

Dr Nathan S Bryan (29:04.974)
Well, the difference about what we do, whether it’s our drug company, we’re developing FDA-approved drugs, or our consumer products division, is we put our products through the theme rigor as drug theory. And most supplement companies, most skin care companies don’t do this. And why don’t they do it? Number one, it’s very expensive. And number two, their products typically don’t work to move the needle on clinical development influence. So I think we have five or six published clinical trials on our skin care product.

Jannine Krause (29:05.294)
Well the difference about what we do, whether it’s in our drug company, we’re developing FDA approved drugs, or our consumer products division, is we put our products through the theme rigor as drug treatment. And most supplement companies, most skin care companies don’t do this. And why don’t they do it? Number one, it’s very expensive. And number two, their products typically don’t work to move the needle on clinical relevant individuals.

So I we have five or six published clinical trials on our skin care product. But what we’re finding is that it opens up the blood vessels and improves oxygenation, improves collagen deposition, improves hydration, hyperpigmentation, kills the bacteria in the pustules for patients with acne, incredible scar remediation.

Dr Nathan S Bryan (29:34.168)
But what we’re finding is that it opens up the blood vessels and improves oxygenation, improves collagen deposition, improves hydration, hyperpigmentation, kills the bacteria in the pustules for patients with acne, incredible scar remediation. What else? It mobilizes stem cells. So our whole philosophy is, if you give the body what it needs, the body heals itself. The human body is regenerative by nature. Sometimes we just got to get out of the way.

Jannine Krause (29:52.153)
What else? It mobilizes stem cells. So our whole philosophy is, if you give the body what it needs, the body heals itself. The human body is regenerated by nature. Sometimes we just got to get out of the way. But certainly it’s a viable and much safer alternative than botox. I think it’s creative how these people, if we’re doing this, they make this acronym, or really an acronym, they shorten the word, but botox is a botulism toxin. It’s a toxin.

Dr Nathan S Bryan (30:02.914)
But certainly it’s a viable and much safer alternative than Botox. I think it’s creative how these companies who are doing this, they make this acronym, or really an acronym, but they shorten the word, but Botox is botulism toxin. It’s a toxin. And why anybody in their right mind would potentially put a toxin, a known toxin, a deadly toxin, in their body is beyond my understanding.

Jannine Krause (30:21.746)
why anybody in their right mind potentially put a toxin, element from, deadly toxin in their body is beyond my understanding.

I agree with you. I even saw in an esthetician’s office something like, have you had your toxin today? And I’m like, yeah, probably 80,000 of them are not putting more in. I’m like, how do we even turn this into marketing? just it’s mind blowing, mind blowing to me. it’s one of those things that I know women are like, I won’t give up my botox. And I’m like, all right, well, maybe we we work on some stuff in between, because back to the circulation thing, I’m always like, this is circulation. We, you know, by no means everyone can see all my marks.

Dr Nathan S Bryan (30:42.625)
That’s right.

Dr Nathan S Bryan (30:47.042)
Be creative.

Jannine Krause (31:01.91)
I love the sun. But how can we help counter this in a way that we’re not injecting ourselves? comical. Us ladies, we’re kind of nutty.

Dr Nathan S Bryan (31:06.99)
Let’s try it.

Dr Nathan S Bryan (31:14.754)
Well, sometimes.

Jannine Krause (31:15.79)
I won’t put you on the spot there. I won’t put you on the spot. I’m saying it for myself, of course. Now, last but not least, one of things I’m going to get because I did go on in my practice some years ago, I got a hold of some samples of the little pads that you test with your tongue for looking to see your nitrates. think it was. And then you put it to hold it together and then you see the levels. Is this real? Did did I get hyped like

Dr Nathan S Bryan (31:21.368)
Thank you.

Dr Nathan S Bryan (31:34.734)
Thank

Jannine Krause (31:45.697)
is this a way to actually tell us anything? Like are we actually able to tell if we’ve repleted our nitric oxide using this thing to see if we’re taking enough? Let me give you the history and the origin story of those test balls. How was the person who developed those test balls 15 years ago when I was still at the University of Texas Health Science Center Houston? I found patents through the university.

Dr Nathan S Bryan (31:55.562)
Let me give you the history and the origin story of those test strips. I was the person who developed those test strips 15 years ago when I was still at the University of Texas Health Science Center Houston. I filed patents through the university. And because that’s old chemistry, it’s probably grease reaction. And what we’re doing is we put an identified sulfonylamide on there and it reacts with nitride and forms this nasal compound. It turns pink. It absorbs at 540 nanometers. And so we thought…

Jannine Krause (32:09.452)
And because that’s old chemistry, probably grease reaction, what we’re doing is we put a spenified sulfanilamide on the reaction with nitride and it this naso compound, it turns pink, it absorbs 549 liters. And so we thought at the time it would give us kind of a dosimeter of nitric oxide for no reason. Because when nitric oxide is produced,

Dr Nathan S Bryan (32:25.366)
at the time that would give us kind of a dosimeter of nitric oxide production. Because when nitric oxide is produced, it’s oxidized to inorganic nitrate, it’s put in our salivary glands, you have the right bacteria to convert the nitrate to nitrate. So these are not nitric oxide test tubes. I abandoned the patents back in 2012. So when you abandon the patents, now any company can manufacture those themselves.

Jannine Krause (32:35.246)
Oxidized inorganic nitrates, put in our salivary gland, have the right bacteria to reverse the nitrates. So these are not nitro-oxidized test tubes. I abandoned the patents back in 2012. So when you abandon the patents, now any company can manufacture those. So we’re piggybacking on our mission thoughts and still using them.

Dr Nathan S Bryan (32:53.006)
So we’re piggybacking on our initial thoughts and still use them. But I don’t use them frequently and my companies don’t use them anymore. And the reason I don’t is because there’s too many false positives. What we’re finding is you can light up that test group if you have an active oral infection. And it could be a symptomatic or asymptomatic oral infection. And so we have the people come in, a 50-year-old, overweight, hypertensive, patient with diabetes and a erectile dysfunction.

Jannine Krause (32:57.87)
But I don’t use them personally, and my companies don’t use them anymore. And the reason I don’t is because there’s too many false positives. What we’re finding is you can light up that test group if you have an active oral infection. And it could be a symptomatic or asymptomatic oral infection. So we have the people come in, a 50-year-old, overweight, hypertensive, patient with diabetes and a real-time dyscompnea.

Dr Nathan S Bryan (33:23.534)
We test him with a test strip and he lights it up like a Christmas tree. He goes, oh, well, I’m good on nitric oxide. He’s had all the clinical hallmarks of nitric oxide deficiency, but he’s lightened up this test. And so then it made me think, what’s going on? So we send him to a dentist, we do a 3D CT cone vein, and he’s riddled with infections. He didn’t even know it. It’s an asymptomatic or dental infection. And so what’s happening is that immune response.

Jannine Krause (33:23.8)
We test this with the test strip and he lights it up like a Christmas tree. He goes, well, I’m good on nitric oxide. He said all the clinical hallmarks of nitric oxide deficiency, but he’s lighting up this test. And so then it made me think what’s going on. So we send him to a dentist, do a 3D CT, a combi, and he’s riddled with infections. It’s an asymptomatic dental infection.

And so what’s happening is that immune response in the mucoses activating nitric oxide production, we’re picking up nitrite and listylized but systemically it’s completely devoid. And so it’s giving people a false sense of security. And really what these test strips are measuring is the presence or absence of the immoral bacteria.

Dr Nathan S Bryan (33:53.366)
in the mucoses activating nitric oxide production, or picking up nitrite in the saliva, but systemically he’s completely devoid. And so it’s giving people a false sense of security. And really what these test strips are measuring is the presence or absence of the oral bacteria. So I don’t use them anymore at these companies. There several companies out there using them. Look, it’s a good engagement tool, and that’s what we were using them at.

Jannine Krause (34:11.182)
So I don’t use them anymore. There’s several companies out there using them. Look, it’s a good engagement tool and that’s what we were using them at. But again, these companies who do not understand the science can’t explain to you what you’re measuring. They’re calling nitropone test tubes and it’s not. Yeah, yeah, yeah. That’s kind of how I played with it at first because if you get something free, mean, why not? I’m going to play with it. Yeah. And so I decided, well, I want to play with it.

Dr Nathan S Bryan (34:20.152)
But again, these companies who do not understand the science can’t explain to you what you’re measuring. They’re calling nitrocoxides test scripts, and it’s not.

Dr Nathan S Bryan (34:36.632)
Yeah.

Jannine Krause (34:41.136)
And it worked great for a minute, obviously it’s something, you know, it’s funny. over the 18 years, that’s the things I keep in the practice and the things that, you know, I don’t, I, it’s very telltale. so, exactly, exactly. And so looking at what you’ve got, I’m like, you know, this is something we definitely want to share with, with our clients. We definitely want to share all of your research because I, when I was looking on your website, I’m like, wow, there’s so much here that I could never, you know, even read in a couple of months, I’m going to have to

Dr Nathan S Bryan (34:51.084)
Yeah, we’ll stick with what works, right? And try new things.

Jannine Krause (35:11.106)
you know, dive in. So let’s share with folks a little bit more on how to find you, a little bit more on your research, and of course how to find your products because we’re going to put that in the podcast notes at drjkrausnd.com. You know, my objective is education and awareness and to communicate the science that’s been past 25 years, you know, discovering and the innovations we brought forward. So I encourage people to subscribe to my YouTube channel Dr. Nathan S. Bryant, like I said.

Dr Nathan S Bryan (35:16.078)
you.

Dr Nathan S Bryan (35:23.448)
You know, my objective is education and awareness and to communicate the science that I spent the past 25 years, you know, discovering and the innovations we brought forward. So I encourage people to subscribe to my YouTube channel. It’s Dr. Nathan S. Bryant, Micrococci. I just published my sixth book. It’s called The Secret of Micrococci, Bringing the Science to Life. It’s on Amazon, Barnes and Noble, wherever books are sold. Follow me on Instagram, Dr. Nathan S. Bryant.

Jannine Krause (35:39.215)
just published my sixth book. It’s called The Secret Microcox head bring the science to life. It’s on Amazon, Barnes and Noble, wherever books are sold. Follow me on Instagram, Dr. Nathan S. Brian, LinkedIn, on PubMed, I’ve published over 100 peer reviewed papers in the scientific literature. And then for those interested in consumer products, it’s m101.com. That’s the letter N, number one, letter O, number one.

Dr Nathan S Bryan (35:51.694)
I’m on PubMed, I’ve published over 100 peer-reviewed papers in the scientific and medical field. And then for those interested in consumer products, it’s m101.com. That’s the letter N, number one, letter O, number one dot com.

Jannine Krause (36:06.19)
Well, thank you for putting all that info out. mean, the YouTube, yes, I could geek out very, very hard there. Now, of course, I have one last question, just kind of for kicks. What does S stand for? Nathan. S in my little name? Yeah. Nathan Scott. have three first names. Gotcha.

Dr Nathan S Bryan (36:18.758)
S in my middle name. Nathan Scott. have three first names. That’s right.

Jannine Krause (36:26.316)
Hey, you know, some people call that power names. That’s good. It’s good. Well, you know, what I found is that people have stolen my identity and we’re using Dr. Nathan Brian dot com to redirect people searching for me to a competitive website. So made it intentional to put the yes in there. So I own the domain and the URL to discriminate from these people trying to monetize what I’ve been doing. it’s so sad. I hear this over and over again for folks. And I’d be lying if I said

Dr Nathan S Bryan (36:30.754)
Well, you know, what I found is that people have stolen my identity and, you know, we’re using drnathanbryan.com to redirect people searching for me to competitive website. So I’ve made an intention to put the S in there so that I own the domain and the URL to discriminate from these people trying to monetize what I’ve been doing.

Jannine Krause (36:56.24)
I didn’t want to know your middle name just so that we could differentiate a little bit because at the end of the day, it’s all about helping folks sleuth out who’s legit, who’s not. And this is where I definitely find those things to be important. know that one. There’s a lot of companies out there that are deceptive. They don’t understand the science. You know, you’ve got ex-CEOs who have no science background and you’re talking about microbe.

Dr Nathan S Bryan (37:09.058)
Yeah, well look, there’s a lot of companies out there that are deceptive, they don’t understand the science. know, you’ve got tech CEOs who have no science background out there talking about nitric oxide. It’s funny. But I take it lightly, but it’s really a serious condition. You know, hear all the time that people will say, Nathan, you talk about nitric oxide and how important it is, but nitric oxide doesn’t work for me.

Jannine Krause (37:24.638)
It’s funny. I take it lightly that it’s really quite serious condition. I hear all the time that people will say, Nathan, you talk about nitro-oxide and how important it is. I can go on and tell you. I’ve been taking this beat product that I saw advertised on TV. It hasn’t helped my blood pressure. It hasn’t had my sexual function.

Dr Nathan S Bryan (37:37.902)
And they go, well, tell me. They go, well, I’ve been taking this lead product that I saw advertised on TV, it hasn’t helped my blood pressure, it hasn’t helped my sexual function. And so it doesn’t work. Nitric oxide works. That product doesn’t work. So that product failed you, that company failed you. And that could kill an entire industry. As we’re developing these technology into prescription drugs through the FDA, if people and the public get the notion that

Jannine Krause (37:47.127)
And so it doesn’t work. Nitric oxide works. That product doesn’t work. So that product failed you, that company failed you. And that could kill an entire industry. Because we’re developing these technology into prescription drugs through the FDA. If people and the public get the notion that

Dr Nathan S Bryan (38:07.542)
Nitric oxide isn’t important, it doesn’t work. It creates an insurmountable hurdle to get safe and effective drugs and product technology approved. So these companies have to be responsible and stop promoting these, or these bead products as nitric oxide because they’re not. They don’t work because they can’t work because these companies don’t understand the science.

Jannine Krause (38:07.788)
Nitric oxide isn’t important, it doesn’t work. It creates an insurmountable hurdle to get safe and effective drugs and product technology approved. So these companies have to be responsible. It’s about promoting these, or these beat products as nitric oxide because they’re not. They don’t work because they can’t work because these companies don’t understand the science.

And I have heard that I am so glad you mentioned I mean, I’ve heard it over and over again and that’s what people think and my husband brought home something he heard on a podcast and was like, hey, try this beep powder. I’m like.

Dr Nathan S Bryan (38:44.28)
Save your money.

Jannine Krause (38:45.23)
It’s and it’s yet so much money too for these things. It does make me cringe and it’s you know why I’m doing this. I want people to hear all of what’s legit. Now in terms of like FDA and all that I know that this process can take a long time. What do you expect in terms of timeline for folks to look at prescription based items out there?

Dr Nathan S Bryan (39:06.894)
You know, I’ve been at this for a while. We had a drug in phase three clinical trials for COVID and we developed a, we established safety of that oral formulation. So now we’ve got a drug, we’re moving into phase three clinical trials for patients with ischemic heart disease. And we’ll start that drug study probably first quarter of next year and then several months. And it’s a very simple study. It’s a 30 day study proving we can prolong exercise induced angiomy without tolerance. So if things go as we expect.

Jannine Krause (39:07.15)
You know, I’ve been at this for a while. We had a drug in phase three clinical trials for COVID. We developed a, we established safety of that oral formulation. So now we’ve got a drug, we’re moving into phase three clinical trials for the condition for the ischemic heart disease. And we’ll start that drug study probably first quarter of next year, in several months. And it’s a very simple study. It’s a 30 day study proving we can prolong exercise induced injury without tolerance. So if things go as we expect,

Dr Nathan S Bryan (39:36.758)
I would expect we would file our drug application end of next year and hopefully have a drug approved on the market by early 2027. And then we’ve got a drug for Alzheimer’s we’re developing, designing the clinical trials now. You know, that’s a little bit bigger, more capital intensive study, I expect within probably two to three years we’ll have that clinical trial finished. And then I’m making a topical drug for diabetic ulcers and non-curing moods. And I think probably within three years.

Jannine Krause (39:37.057)
I would expect we would file our drug application end of next year and hopefully have a drug approved on the market by early 2027. And then we’ve got a drug for Alzheimer’s we’re developing, designing the clinical drugs now. That’s a little bit bigger, more capital intensive study, expect within probably two to three years we’ll have that clinical trial finished.

And then I’m making a topical drug for diabetic ulcers and oncology. And I think for probably within three years, we’ll have that completed. These are big time projects. I’ve been very intentional. have bootstrapped these. I funded this myself for the most part. But these drug studies take tens of millions of dollars. And in the process of raising capital, I’ve turned down money from private equity, from venture capital.

Dr Nathan S Bryan (40:05.538)
have that completed. These are big time projects. I’ve been very intentional. I’ve bootstrapped these. I’ve funded this myself for the most part. But these drug studies take tens of millions of dollars in many years. In the process of raising capital, I’ve turned down money from private equity, from venture capital, because I will never abdicate what we’re trying to do to an outside firm that would be in control. I’m not building it to sell it.

Jannine Krause (40:27.854)
because I will never advocate what we’re trying to do to an outside firm that we think control. I’m not building it to sell it. So I’m not interested in private equity. I’m building it to do the right thing. I’m not sure that everybody around the world has access to safe and effective product technology.

Dr Nathan S Bryan (40:35.182)
So I’m not interested in private equity, I’m interested in money. I’m building it to do the right thing and to make sure that everybody around the world has access to safe and effective product technology.

Jannine Krause (40:46.466)
That’s awesome to hear. That’s awesome to hear. Because at this day and age when we’re seeing different companies come up, then boom, they’re sold within a couple of years after they make some money. Boom, they go and then things happen. Or companies, supplement companies, get sold. Yeah, then they show the technology. What we do is extremely disruptive. And it’s not outside the scope of imagination that a big farm, a billion dollar company would come in, bring me a billion dollars, and then show the technology.

Dr Nathan S Bryan (40:58.158)
Yeah, then they show the technology. What we do is extremely disruptive. And it’s not outside the scope of imagination that a big farm, billion dollar company would come in, bring me a billion dollars and then show the technology. Because it’s going to disrupt their market share.

Jannine Krause (41:14.456)
because it’s gonna disrupt their market share. But I’m not for sale. Good to know, good to know. That speaks volumes, that speaks volumes. And definitely in terms of choices that I make, things that I recommend to folks, and just definitely how I’m going forward in this, because unfortunately, from where this industry started, even…

Dr Nathan S Bryan (41:19.928)
But I’m out for sleep.

Jannine Krause (41:41.505)
over 20 years ago when I got into the naturopathic medical school till now, mean, it’s disgusting what’s happened. Yeah, no, I think the time look Integrity and honesty and trust rules today So I predict as we start continue to advance the science and are calling out these companies that are before these products that don’t work because they can’t work They’ll go away

Dr Nathan S Bryan (41:47.586)
Yeah. Now I think the time, look, integrity and honesty and trust rules the day. And so I predict as we start, continue to advance the science and start calling out these companies that are putting forth these products that don’t work because they can’t work, they’ll go away and the cream will rise to the top. And, you know, there’ll be a flash in the pan, it’s not sustainable because what we’re doing, what you’re doing, podcast and reaching people.

Jannine Krause (42:05.038)
and the cream will rise to the top. There’ll be a flash in the pan, but it’s not sustainable. Because what we’re doing, you’re podcasting, reaching people outside mainstream media, consumers become informed and aware and very discriminant so they can make educated and informed decisions. And if you the truth out there and the science wins, people will no longer buy from these companies. They’ll be forced to do something different, do out of business.

Dr Nathan S Bryan (42:16.288)
outside mainstream media. know, consumers become informed and aware and very discriminant so they can make educated and informed decisions and if you the truth out there and the science wins, people will no longer buy from these companies and they’ll be forced to do something different, go out of business.

Jannine Krause (42:34.958)
It makes sense, it makes sense. Now of course you kinda drop the bomb on the diabetic ulcer topical and there’s one more question I have to ask because I am one of those folks, I see a lot of folks who really sensitive to taking things orally.

And topical tends to be sometimes more of a preference because nervous system fear, let’s just put it that way, of taking things and having reactions. Can you have a nitric oxide product that you just take topically instead of orally and replete at the same manner?

Dr Nathan S Bryan (42:56.642)
Yeah.

Dr Nathan S Bryan (43:10.414)
Probably not, because you have to understand nitric oxide’s a gas. And there’s a limit of diffusion of the nitric oxide that we’re applying topically. It’s only going to diffuse a couple of millimeters into the tissue. But the point is, it’s not going to reach the conduit, the resistance, arterioles, and arteries. It’ll dilate and recruit capillaries and dilate superficial blood vessels. But yeah, probably not.

Jannine Krause (43:10.798)
Probably not, because you have understand nitric oxide is a gas. Yeah. And there’s a limit of diffusion of the nitric oxide that we’re applying topically. It’s only going to diffuse a couple of millimeters into the tissue. But the point is, it’s not going to reach the conduit, the resistance, arterioles, and arteries. It’ll dilate and recruit papillaries and dilate superficial vessels.

Yeah, probably not. Because what we’re developing is a topical drug, it has a local effect that only affects where it’s applied. So if it’s a topical, that becomes systemic, then that’s a different class of therapy.

Dr Nathan S Bryan (43:36.13)
Because what we’re developing in terms of a topical drug has to have a local effect and only affect where it’s applied. And so if it’s topical that becomes systemic, then that’s a different class of drug therapy.

Jannine Krause (43:50.83)
mean, yep, makes sense. Makes sense. So those of you out here who are thinking like you could use this, this get the serum for your face. It’s not going to get in internally. You got to use both noted. That’s the point of the laws. We want to hit it topically and superficially. So we’re the skin and body inside. Makes sense. Makes sense. Wow. My mind is blown. I’m going to get I know you have six books and definitely folks, I will put all of them

Dr Nathan S Bryan (44:00.168)
That’s It’s inside out because we want to dilate the blood vessels internally. That’s the point of the lozenge. We want to it topically and superficially. So we’re hitting the skin and the body inside of it.

Jannine Krause (44:20.836)
at drjcrossnd.com I have them listed out so you can see all of them because it’s just such fascinating information and what I have been able to dive into it just blows my mind. Thank you again so much. Thank you. I really appreciate it. Well good luck with that documentary today and we will look forward to putting this podcast out really soon. Okay thank you. You’re welcome. I’m gonna stop.

Dr Nathan S Bryan (44:33.432)
Thanks so much. Thank you. It’s been an honor.

Dr Nathan S Bryan (44:43.734)
Okay, thank you.