Ep 538: Epigenetics and Longevity: Rewriting Your Health Story With Hannah Went

In this episode of The Health Fix Podcast, Dr. Jannine Krause interviews Hannah Went, co-founder of TruDiagnostic, to discuss the revolutionary role of epigenetics in health and aging. Learn how TruDiagnostic’s TruAge test analyzes DNA methylation to calculate biological age, empowering you to make personalized lifestyle changes. Discover how tools like the Biobank/Harvard’s OMICm Age Algorithm, Yale Symphony AGE, and DunedinPACE analysis can predict and prevent chronic diseases while improving longevity. If you’re looking to take control of your aging process and improve overall well-being, this episode is packed with actionable insights.

Takeaways for Listeners:

• Genetics isn’t destiny—your choices and environment play a pivotal role in health outcomes.
• How tracking your biological age with TruAge can empower you to make data-driven lifestyle changes.
• The potential of epigenetics to predict and prevent chronic diseases, giving you tools to live a longer, healthier life.

Resources Mentioned:

• TruAge + TruHealth Testing – TruDiagnostic Website
• Hannah Went’s Podcast: Everything Epigenetics Podcast

Tune In and Take Control:

Join Dr. Jannine Krause and Hannah Went for an inspiring conversation that reveals how epigenetics can help you age gracefully and reclaim control over your health journey.

Our Partners

Podcast Transcript

1:09 – Intro

5:29 – TruAge

12:07 – What goes into the algorithms

21:34 – Symphony age

22:31 – Musculoskeletal  age

28:35 – DunedinPACE

32:27 – Heart biomarkers

37:22 – Perimenopause and menopause

43:18 – Where to find Tru Diagnostic

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[Preview] Even it’s going to be like a nutrient-eval and like a vibrant health report combined.

So, vitamin levels, amino acids, methylation markers, antioxidants, minerals, and healthy

fats, those are really more of like the nutritional-based outcomes.

And then we even have general health markers too.

So it goes above and beyond just like a traditional nutrient-eval.

So we’re looking at metabolic markers, immune markers, bone and mineral, hormonal, neurocognitive,

microbiome inflammation, stress markers, toxins, so some of the PFAS, some of the forever chemicals,

mitochondrial function, oxidative stress, NAD metabolism, ketones, and even supplements as well.

So quantifying all of those levels to be able to say, “Hey, where am I deficient? And where can

I actually start to make a difference?” They’ve looked at some estrogen supplementation too,

alongside of the menopause, and that can definitely help mitigate the accelerations that we’re

seen within the biological age.

[Intro] Welcome to The Health Fix Podcast, where health junkies get their weekly fix of tips, tools,

and techniques to have limitless energy, sharp minds, and fit, physiques for life.

JANNINE: Hey, Health Junkies.

On this episode of The Health Fix Podcast, we’re going to be talking about the power

of epigenetics in shaping your health and how the company True Diagnostic is offering

cutting edge insights through DNA methylation analysis to empower individuals to track their

biological age and make personalized lifestyle changes that can positively influence how well

they age and their overall well-being. The science of epigenetics reveals that while genetics may

load the gun, it’s our environment and choices that pull the trigger, meaning you have the ability

to rewrite your health trajectory.

And so I’ve brought Hannah went from true diagnostic back on

to his honor a couple of years ago.

And Hannah has quite the passion for longevity

and breakthrough technologies

that drive improvement to the human condition.

And of course, that’s what we’re gonna be talking about today.

How can you improve your aging?

Now, true diagnostic has a commitment to research

with over 30 approved clinical trials,

investigating the epigenetic methylation changes

of longevity and health interventions.

Since true diagnostics inception,

they have created one of the largest private

epigenetic health databases in the world

with over 35,000 patients tested to date.

Now Hannah also has a podcast

and it’s called Everything Epigenetics

where she shares insights on how DNA regulation

has an impact on your health.

So today, Hannah and I are going to go through

my October 2024 results and compare them

to my 2022 results and talk all about the upgrades

to true diagnostics testing,

but also we’re gonna go into the Duke

and a couple other universities combined

DUNID and PACE testing and talk about Yale’s

symphony age testing and how these two tests combine are what true age testing from true

diagnostic are and and how they’re there to help you identify your pace of aging and what you can

do to slow it down. So this is a fascinating podcast where Hannah kind of dives in with me to show me

what was going on with my aging and thank goodness things aren’t looking too bad but there’s a couple

twists and turns in in this podcast. So if you’re wondering how I stack up on my aging and you’re

also curious about if a true age, true diagnostic test may be something for you to look into to

help with preventing things or just knowing where you stand when it comes to your aging,

this is the podcast for you. So let’s reintroduce you to Hannah Went. Hannah Went, welcome back to

to the health fix podcast.

HANNAH: Thanks, Dr. Krause.

I’m excited to be here today and chat with you more.

JANNINE: Man, it’s been a little bit,

so we of course were catching up before we hit record

and I’m glad to have you back

’cause I was gifted the chance to test myself again

and see where things are at.

And of course, you guys have changed things up.

And so I had a little bit of a panic,

like I was saying, I saw that before I was seven years younger,

now it shows I’m still younger than my actual age,

But it’s at a less of a rate, but when I look at all the data, it looks like things have improved,

except one thing, my musculoskeletal health, and we’re going to talk about that today, and what the

heck happened. So thank you so much for coming back on. I appreciate it.

HANNAH: Yeah, yeah, I’m happy to help. I’m excited to dive into some of your results as well. It’s

really exciting when people have two data points, right? Because then you can start to ask yourselves

the question like, hey, what happened in between? What did I do? What can I get better at? And I know

you’ve had a move and have probably done things in between the tests as well. So we’ll try and,

you know, work through those and see how or why you improved. We can even talk about some of the

differences within like the epigenetic clocks to the biological age outcomes and like why we

made some of those report changes as well. 

JANNINE: Yeah, definitely, definitely. So guys, stay tuned,

we’ll get there. I want to definitely bring up like what is this test all about? What markers

are we using? Because the true age really, let’s put it this way. It’s very clear looking at the

organs and it helps me to really see what’s going on. But the true age is really a combination

of algorithms, correct? So give us the scoop as to what we’re looking at with the combination.

HANNAH: Yeah, I think first and foremost aging is so complicated. It’s so exciting, but I think we’d

be naive to think like, oh, there’s this, you know, one biological age that rules them

all, right? It’s like tells us about our destiny and where we’re supposed to end up

but in life and what diseases we would get, et cetera. We just know that’s not true, right?

We’re aging at a cellular level. Each individual cell in your body is having its own kind of

biological age ticking clock too. So what we do at True Diagnostic with this, and kind

of you mentioned, individual or different biological age clocks is give you a good handful of

them to use synergistically or together to then make a recommended

interventional treatment planar protocol afterwards too. So we really

have three that I think excel at this. We have our Omik M age that stands for

looking at the inner like looking at how your and multi Omik is functioning

from a part of your body. So in our working clinical lab values,

metabolites and proteins through an aging score.

That was one we created with Harvard.

We then have the one you mentioned called Symphony Age.

So this is the aging of 11 different organ systems.

We just released.

It’s a really, really cool set of ages.

We have your metabolic age, brain age,

immune system, hormone, heart, kidney inflammation,

liver lung, musculoskeletal and blood.

So again, you start to get a little bit more targeted

in those treatment recommendations

because you can see where you’re aging the fastest

and that one we created with EA-All.

And then I think my favorite,

and when we were chatting about just a little bit ago

before we hopped on, is that pace of aging metric, right?

The denninged in pace when we created with

Duke and Columbia University,

that’s just a different kind of measurement.

It’s more of a speedometer, right?

How quickly you’re aging biologically

for everyone chronological year.

JANNINE: Yeah, and that one was one that when I first saw it,

I was like, “I’m not doing the great,

but then when I compared it to before,”

I was like, “Oh, wait, I have improved.”

And it’s crazy how you look at it

and you’re like, “You go right to the negative.

What’s up with us humans?”

HANNAH: Yeah, yeah, you really do.

I think again, looking at all of them,

looking at them longitudinally,

just like you did is really key to start to say,

“Okay, well, how are these clocks moving?

What am I doing?

What am I feeling?

And where do I want to go in the future?

Right?

I hope you take it and, you know, three or four months

or, you know, six more months.

So we can start to even look at those trends

a little bit further.

JANNINE: Yeah.

Well, and this is kind of where things have kind of evolved

right with my practice and definitely looking at aging

and trying to help folks really understand

where to focus on their health.

Because I think for a lot of us,

if we’re more or less feeling okay,

maybe we’re a little tired,

maybe we’re feeling a little bit like run down,

maybe we’re not sleeping is great,

But we’re like, yeah, for all, I’m pretty good,

but I would like to make it better.

This makes sense to do.

HANNAH: Yeah, yeah, and I think, you know,

when True Diagnostic opened

about four and a half years ago,

I did see that a lot, right?

People who were like already optimized, you know,

they did all the blood work,

they had their hormones in check,

they’re like, what’s next?

What’s the next greatest, you know, big as seeing?

And then it kind of comes back to aging, right?

I already feel good, but what’s that one thing

I could measure that one thing I could work on

and again, aging being that number one risk factor

for all cause mortality and morbidity,

it’s a great place to end up that

after you’ve optimized or tried to optimize everything else.

But more recently, I see healthcare providers

doing this on their patients

right when their patient walks in the door,

which is really cool ’cause they’re like, wait a second.

We wanna see the change all the way from maybe that

unhealthy or version of you to optimization.

And those results can look really, really nice over time.

JANNINE: Well, it makes a lot of sense

because I think when we’re working

on lots of interventions,

I mean, the biggest thing I hear from a lot of people is,

am I making, am I making progress, right?

Am I, you know, how do I know?

I don’t necessarily, I didn’t necessarily come in

feeling bad, right?

You know, and so a lot of people are like,

well, I don’t know, am I making progress, am I not?

But if we do come in, you know,

how folks come in who are really trying

to rejuvenate their health and revive themselves,

and it looks for, I mean, this would be like a great thing

to look for to see like, okay, where are our efforts working

and where do we need to put more efforts?

HANNAH: Yeah, and I think that’s where we are today

with a lot of the outcomes on the reporting too, right?

When you first took the test, the insights were rather limited.

We didn’t really give you recommendations.

It was kind of, you had these, you had a couple ages,

you were either older or younger and you’re like, yeah, okay.

Well, now what I’m older or I’m younger.

It was kind of like a novelty,

but it gave you very limited insight,

let’s say, into your aging process.

Whereas now with kind of integrating different layers

from the multi-ome, integrating different organ system levels,

we’re actually able to pinpoint and say,

okay, well, you’re aging a little bit faster because of this.

Let’s try these lifestyle factors or these supplementations

or maybe it’s even medication

or like a procedural-based therapy.

like hyperbaric oxygen chamber therapy or, you know, therapeutic plasma exchange, right?

Some of those larger and interventional treatment plans.

And that could be, you know, worked out with your healthcare provider.

I definitely recommend taking the test through a healthcare provider who’s trained in this

area just because they’re going to first off know you best, but know the test interpretation

best too.

JANNINE: Yeah.

Yeah.

That makes sense.

That makes sense.

I think a lot of people might be thinking right now, like, okay, so you mentioned the

the Dune it in. You mentioned you worked with Harvard or not Harvard, sorry, with Yale.

And then you worked, you know, we’ve got Duke. Now, how do Harvard probably has to come in

here somewhere, I’m guessing, since we’ve got all-

HANNAH: We work with Harvard too. Yeah, yeah, you’re right.

JANNINE: Okay. So there is, yes, that’s right. There’s the Harvard and the BioBing too. Okay. So I

wasn’t completely off, but I’m like, you’ve got all the top universities there. But I think

a lot of people might be thinking like, okay, so this is DNA. And we’re running algorithms

on the DNA now help us to understand the algorithms here.

We’re working off a methylation on some and so give us kind of the background so folks

can understand like what’s actually being looked at as the basis for the algorithms.

HANNAH: Yeah, that’s a great question.

So we’re quite literally looking at your genetic expression levels, right?

Think of it almost like a not necessarily light switch but a light dimmer where you

could have these different expression levels of your genes.

It’s called DNA methylation, essentially looking at a CH3 group, a teeny tiny carbon

and three hydrogens.

And if that’s present, your gene expression is turned off.

But if that is not present, you’re unmetallated that gene expression is turned on.

So it’s a, it’s a balance.

I always say, hey, we want to shift our methylation markers in our favor.

It’s not the goal of having all of our genes turned on, right?

Or all of our genes turned off.

We definitely want to pick and choose the good and bad ones regarding how they actually

function later on downstream. So that’s what we’re measuring here in our lab in Lexington, Kentucky.

It’s just a fingerprint blood spot card. We’re going to use a blood sample because that’s where

these algorithms have been trained and invalidated in as well. But to your question, well, how do

you actually create these algorithms or these clocks? We look at about a million positions of

those DNA methylation positions on your sample. And the more other biological information that

that we stack on top of that, like clinical lab values

in the training, proteins, metabolites,

different functional markers as well, like VO2 max,

FEV1, grip strength, gate speed, right?

We’ll pour everything, all these markers into the training

so then we can actually impute those outcomes

just through the lens of DNA methylation

or epigenetics itself.

So the more information, right, the better,

and we partner with people like Harvard,

mentioned in their bio bank too because you need that outcome data, right?

So say for example, we take a 20 year old from the bio bank, you know, we have

their methylation data from that point.

And then they passed away at 80 years old from a cardiac event, right?

At what point in their life did their methylation markers change?

And how can we use those to then predict say a cardiovascular risk marker at some

point?

JANNINE: Wow.

It’s so fascinating how much access we have to all of these things and how we can use it

for our health.

I know a lot of people, you know, DNA, when we first talked about it way back a couple

of years ago, folks were kind of still a little bit like, “Oh gosh, I don’t know if

I want to use my DNA.

I don’t know if I want to, you know, give it up and get some info.”

But I mean, I’ll be honest, like I do a lot of DNA testing too.

And it’s hard to really get like with all the SNPs like, okay, I can see the info, but

I can’t.

It’s hard to like guess how someone’s going to age with it, right?

Like you don’t know like is something really going to happen?

Is it happening?

So this is a great way to pair the DNA testing to see your genes and then also pair it with

this to see like what’s actually coming true for you.

I guess you could say what’s your happy.

HANNAH: Yeah.

Yeah, I like that.

Yeah.

And you mentioned now you don’t really know how someone’s aging.

I mean, there’s correlation right with with

quick strength, eight speed cognitive function and even facial

aging with a lot of the biological age clocks, but you really just don’t know.

And I do think it’s great to pair the epigenetic testing with your

genetic testing.

My cell, for example, I’ve had my genetic testing done.

I have the APOA 3.4 variant.

My grandmother passed away from Alzheimer’s.

I have a 20% increased chance of being diagnosed and at an earlier age as well.

So that’s so scary to me, right?

It’s not going to change though.

That’s just my genetics.

However, that is what it is, right?

It’s just a genetic predisposition in risk.

It’s not my epigenetics, which is actually modifiable.

So there are a lot of studies out now, of course, talking about lifestyle factors.

You can do to help lessen that.

of Alzheimer’s, but also even things like estrogen therapy too and supplementation to

reduce that risk or that genetic variant.

So yeah, there’s a lot of really cool connections and ways these fields, both epigenetics and

genetics play together.

I think it makes for a really, really great combo offering on someone.

JANNINE: Yeah.

Yeah.

I’ve been thinking about it lately, just kind of looking back at my DNA testing and then

looking back at this and then like, “Oh, wow.

Wow.

Wow.”

Of course, we want to dive into my results

so that folks who are listening

will give you a good audio version of it.

If you want to see it, I’m gonna have it over on YouTube,

my channel there, the Health Fix Podcast.

So I want Hannah to kind of go through my results with me

and we’ll kind of like talk about what’s showing up.

I can give you my, I have no shame.

I’ll tell you what’s going on in my life

and what’s changed in fact.

I’m excited to show it because things have improved

so it makes me happy to be able to show it.

So let me quick do a screen share here.

So we’re going to take a second.

So here’s my report.

And it’s me.

You can see my name here for those of you who are watching it

visually.

Yes, I’m 46 years old at the time of this recording.

I have no shame about my age either.

And so here’s the–

tell me how to say this.

And what this means for folks between my chronological age,

which is 46.22, and my–

HANNAH: Homic, M-H.

– Homic, M-H.

– Homic, M-H.

– It looks so good.

Anyone who is younger just biologically

should be happy and should be impressed.

It’s not easy to do, right?

Like we’re doing things all the time

that make us age quicker.

I mean, even just in America, right?

Kind of the nine to, you know, five PM, six PM, right?

Work week and, you know, high stress a lot of times

we put ourselves in and in our environment. So we traditionally expect people to age a

little bit quicker, but you’re younger. So this is something you should definitely be

proud of. Keep in mind men in general, age quicker than women. So for those listening

who are male, you know, you die younger, you age quicker than women, you may see these

numbers a little bit more accelerated. We definitely do from a population based standpoint.

JANNINE: Makes sense, makes sense. And this is where I kind of panicked because last time I was

seven years younger. And now I’m just a little hair under a year younger. But the, so for folks

who heard my previous podcast, we, the algorithm was changed, correct, in terms of that, just so

folks can hear that. It’s not like I’ve, I’ve now only been less than a year. It’s different

algorithm. 

HANNAH: Yeah. Yeah. And, and really that gets into the kind of the creation of these

biological age clocks and epigenetic clocks, as we were talking about earlier. Those previous

ones we had were first generation clocks. So they were really just trained off of

chronological age and DNA methylation. As we mentioned, this one right here is called a second

generation clock. It’s actually trained off of your metabolites, your proteins, your clinical lab

values in methylation as well. 

JANNINE: Nice. So of course I’m competitive and you have the

the rejuvenation Olympics and things of that nature.

What’s like the running person right now?

How much younger are they than their chronological age?

Who’s on top?

HANNAH: Yeah, the rejuvenation Olympics

just really quantifies that piece of aging metric

because it is so good at capturing change

in a very short amount of time.

And I think the person in first place has like a point,

I wanna say it’s like zero point,

like five, six or something like that too.

If you go to rejuvenationallympics.com,

you’ll be able to see it.

And to be at the top or like verified

with the blue check mark,

you need three Dunedin pace test over the last two years.

So yeah, I think it’s around that.

JANNINE: Wow.

You might have gamified this for me to see what it is.

HANNAH: Yeah, we’re getting into that competitive head of yours,

that spirit.

JANNINE: Yep, yep, definitely for sure.

So we have this one and then if we move down,

here we have the actual kind of number here

and if you can explain this here a little bit for folks.

HANNAH: Yeah, definitely.

So it’s again, going over,

hey, your Homik M age is lower than your calendar age

by about a half a year.

You see that little smiley face there,

you’re doing a great job.

And then your Omik image is actually lower

than about 45% of people too, same age compared to female.

So you’re doing really well against the population

right around average.

JANNINE: Score, score.

I wanna be above average, so we’re gonna have to work on that.

So if we look down here, we can see kind of what showed up

before for me, and I was a lot different in 2022

in terms of age as a whole,

but as we’ll see below,

organs are vastly different in terms of aging.

So we’ll have folks kind of see this difference

is for me before me now.

HANNAH: Yeah, yeah, definitely.

And the symphony age is one that we absolutely love.

Again, it was an approach looking

into individual organ systems.

This talks about the idea of heterogeneity, right?

We all don’t get liver disease or heart disease

at the same age.

We know our organs are ticking at these different rates.

And that’s exactly what this clock does too.

So you can see here, kidneys look good,

your aging slowly, lungs look great,

inflammation looks good, hormones liver,

aging slowly on all of these.

You have metabolic aging slower.

Oh, and here we have the ones that are aging faster.

Brain just a little bit,

blood just a little bit faster, immune just a little bit

faster, heart just a little bit faster.

Musculoskeletal is definitely what’s bringing that kind of like, you know,

average of all of the scores up together, right?

So this is interesting.

Um, the musculoskeletal score.

So this is trained off of a lot of like.

Musculoskeletal, I guess, based biomarkers, um, vitamin D three, for example,

IGF-1 arthritis, height, weight, BMI, and then a ton of mobility metrics as well.

Like, balance, time test, grip strength, like even recollection or charting of like previous

back problems or like kind of how you carry weight, right?

Semis, seven different functional tests, combination of individual balance tests and

grip strength, stair climbs, you know,

tandem balance test all the above.

JANNINE: Wow, which is so fascinating because I am a workout junkie.

I lift weights all the time, right?

So for me, it goes and balance and in agility and all those are all my jam.

But I’m like, I wonder since I did this test before I her needed my L5S1 disc.

And I’m like, I wonder if that threw off like a huge thing in my.

HANNAH: Yeah, I was gonna, so my first question to you was like,

were you hurt?

That was gonna be my next question.

Like were you hurt, you know, had some more mobility issues.

Obviously that’s, you know, cannot feel great.

Probably took some time off, right?

As well, do you know, when did you hurt that

compared to when you took this test?

JANNINE: It would have been actually two years ago,

but I’ve had on and off flares.

HANNAH: Oh, okay, okay, gotcha.

Yeah, yeah, interesting.

Interesting. Was it, yeah, was it the situation just pretty bad?

What did it put you down for a while?

Or?

JANNINE: Yeah. Yeah. So we think what, I mean,

I’ve been powerlifting for years,

probably started some things back then,

but we were reroofing the backside of our house

when we first moved in two years ago.

And I think that at that time,

I, what happened is just carrying the shingles up the ladder as well.

HANNAH: Oh, okay.

JANNINE: So yeah.

Yeah.

It’s to see this, I was like, and that’s like my big thing.

In addition to the problem circulation, which may like baffles me.

HANNAH: Yeah.

Yeah.

The musculoskeletal age itself, what’s really cool about these individual

systems ages essentially is they’re super predictive of individual morbidities, right?

We look at that Omik M age and the Omik M age is like a lifespan predictor.

Think of this as more of like a health span predictor, right?

So for musculoskeletal, it’s super predictive of physical function, just total comorbidities

in general, and then diabetes and arthritis as well. I’m wondering if you have any like family

history of like diabetes or arthritis too. Because again, I mean, we’re picking up an epigenetic

signal, but even epigenetics to an extent can have some type of like genetic right connection too.

JANNINE: Yeah. Absolutely. Arthritis is a thing. However, my 88 year old father is so mobile,

it’s like out of control. He was helping us roof the house and– 

HANNAH: oh no way.

and like he’s incredible. My mom didn’t live long enough. She passed at 62 of breast cancer.

So I don’t really know on her end, but I do know my mom’s family diabetes, my dad’s side,

my dad’s had a quadruple bypass. So there is cardiovascular stuff, which makes me wonder like,

okay, my heart’s aging faster, my blood. What should I be looking at here? Like, what do I do?

HANNAH: Yeah, yeah. But what is an interesting one? The biomarkers that are going to be measured in,

you know, the blood age are going to be your like, think of like a CBC, right? Your Farritin,

Hematocrit, Hemoglobin, mean, Corpolar Hemoglobin, Red Blood Cell Distribution with Red Blood Cell

Count, Platelet Count. The blood age in particular is predictive of leukemia and cataract, interestingly

enough. But your blood age isn’t like super old by any means, right? You’re just a little bit

elevated there. So if you had your bloods taken around that time to, definitely something to dig

into. 

JANNINE: Well, it’s definitely like a red flag for me, especially that

musculoscalital that that freaks me out. I’m like something I’ve got to

change something here in terms of my body. And you know, yeah, I’ve got to

figure that out. So anyway, I find it fascinating as to like what what

happened here. And like literally, if we look at from 2022 to 2024, out of

All of the things, the biggest jump was muskulotskeletal.

HANNAH: Yeah.

JANNINE: And I’m like, wow, what in the heck?

HANNAH: And you got injured, you said two years ago,

after you took the first test.

JANNINE: Yes.

HANNAH: Yeah, that’s crazy.

I wonder, I mean, obviously there’s a connection there, right?

Interesting.

Yeah.

JANNINE: I find it interesting too that like,

when I look at things across the board,

I am besides the Mosquito skeletal blood

And blood, really, most things are actually looking better for me.

Um, some stay kind of similar, but really looking across the board, I’m like, okay.

So the move was good for me, but my heart, my, my musculoskeletal and blood need a little TLC.

HANNAH: Yeah.

Yeah.

Most of it went down though.

Yeah.

It looks pretty good.

So I think just worked on that musculoskeletal age, you know, a little bit of a deeper dive there.

And, um, you know, I’m sure it gets better every single day to regarding your, your back.

Um, but yeah, super interesting.

JANNINE: It is, but you know, it’s a, it’s a good wake up call.

It’s funny because it’s the three things I talk about circulation.

A lot of my podcast with my patients, keeping your muscles strong, working on our

muscles.

And then you’re working on the heart and cardio and like HRV.

So it’s hilarious that those would be the three.

So I’m like, all right.

Well, I guess like I’m working on myself.

HANNAH: We all are.

We all are.

JANNINE: So let’s move on to the DunedinPACE here and talk a little bit about this guy here.

HANNAH: Yeah, yeah, I love the DunedinPACE. This is an awesome clock. This is the one we worked on with

Duke and Columbia University. It’s different. As you can see, you’re like, wait, this is like a

ratio or what does it really mean? So this tells you how quickly you’re aging biologically for

for every one chronological year.

So this looks great.

You’re at 0.8.

It means you’re aging 0.8 biological years

for every one chronological year.

Obviously you want to be as low as possible here.

Again, this is pretty famous

regarding the rejuvenation Olympics

that we have a competition where you’re comparing

these scores with other people

and just trying to compete to get it as low as possible.

So this one is really responsive in short periods of time.

people even do this like every eight weeks or you know, 12 weeks, if you really, really

wanted to start dialing down and trying to slow your aging.

This is a really, really great clock.

JANNINE: Wow.

Wow.

Well, I looked at that and of course I was still hung up on the seven years, but I did

notice that my results over time, I was at 0.92 before.

HANNAH: Okay.

Yeah.

You went down.

Yeah.

I mean, you know, a lot of your ages went down.

It would make sense that this is a little bit lower as well.

So I wish like it would have been interesting to see when your injury happened, right?

And where your DunedinPACE would have been there.

So this is absolutely one if you’re like really dialing in on the aging stuff you want to

do a little bit more consistently just so you have those those data points.

JANNINE: So important.

So important.

Now here’s one thing I would love for you to talk about and I’m going to stop my share

here.

Is that pace greater than one and the resource of death tell tell us more about that lake.

scary. 

HANNAH: Yeah, yeah, it is. So again, all of these AG markers are going to be, you know,

really predictive of mortality and morbidity. For example, that Omik M age can really predict

death with a 92% accuracy rate, whereas chronological age is just 72%. Right. Chronologically, just

still going to be predictive of death itself, right? Because we know as we get older, we are

developing these diseases, we’re more likely to pass away. And same thing with the, the

that DunedinPACE essentially, right?

It’s just another biomarker indicating,

“Hey, if this is above one,

like if you’re aging faster biologically every year

for everyone chronological year,

you have about a 50% chance for mortality,

morbidities in the next seven years.

One’s 54%, the other is 56.”

So we really wanna do whatever we can to keep that below one.

I think that’s super, super important.

And actually, you know, caloric restriction seems to be working the best on on DunedinPACE.

We really need to go and and validate a lot of these kind of therapies through large clinical trials.

But there was a caloric restriction trial posted a couple of years ago, showing a pretty significant decrease in the DunedinPACE.

Well, you know, with intermittent fasting, those things on showing benefit, I mean, it kind of makes sense.

Right.

I think a lot of people are starting to realize that and well with the success of the GOP ones

we might be having a lot of folks you know being able to to drop their their caloric intake you

know using using medications and maybe get themselves a couple more extra years in life here but

all that being aside I’m a naturopath so obviously I’m I’m kind of trying to figure out how to do

things naturally and where to go about this now of course let’s use my example since they were there

And we have musculoskeletal, we have the blood, we have the heart.

What kind of things would you be thinking for folks in terms of interventions?

What kind of things would you be kind of talking about for folks to look into?

HANNAH: And then yeah, I know we went over the musculoskeletal biomarkers that we have

and the blood.

Let’s go over the heart real quick.

So this would be interesting to pick your brain about too.

So the heart biomarkers include shortness of breath while awake.

components of another clock actually called Grim Age, which is a super great predictor for

just mortality. Previous high blood pressure, previous heart attack, previous stroke, homocysteine,

and BMI as well. And the heart age is really predictive of physical function, total comorbidities,

coronary heart disease, diabetes, it does a good realm of disease prediction. So yeah, we’re

We’re seeing a little bit of a theme here, I would say,

in terms of a couple biomarkers I may just check in on.

So for example, the homosysteine within the heart,

calculation, the vitamin D within the musculoskeletal,

and then all the blood-based values, I would say as well,

with those biomarkers.

So definitely again, this isn’t a replacement

for your traditional lab test, right?

Or blood-based values.

So looking into all of those that I just named,

My GF1 was another one on there as well.

Do you have an MTGFR variant?

JANNINE: I do not.

HANNAH: Oh, you do not, okay.

JANNINE: I think for both of those.

HANNAH: Okay, perfect.

I thought you were shaking your head, yes.

I was like, yeah, no, okay, perfect.

And then, yeah, I think physical function, right,

is something I think to watch to.

So you mentioned you’re a power lifter, usually, right?

Are you doing a lot of aerobic based exercise too?

I do sprint training twice a week.

HANNAH: Oh, wow.

Good for you.

JANNINE: Working with– I haven’t been doing the long–

I used to do marathons for years and years.

If I look at what was I doing in 2022 compared to now,

I was probably running a little bit longer of distances.

That–

So it makes me wonder a little bit if maybe that

could be a little bit of something here.

HANNAH: It could.

Yeah.

Yeah.

And again, I think really focusing on–

just you mentioned, you know, being a naturopath, really wanting to solve this holistically

more right, I think is such a good point. So we always see lifestyle factors moving the

needle the most. I mean, the four main ones, of course, being your stress, your sleep,

your nutrition, and your exercise. And I think that’s just a really, really good starting point.

Outside of that, you know, you can do an evaluation on your alcohol patterns in terms of consumption,

right, smoking status, insulin sensitivity is huge as well, I would say, and then toxicity,

right? So reducing toxins. By all means, if you can, right, we can’t be perfect in every

category, but I know you’re a super healthy person, you know, in and of itself, right?

You practice what you preach. So yeah, I don’t know. The musculoskeletal one is really,

really throwing me off. How many days a week do you power lift?

JANNINE: I’m lifting about four days a week with the light lift on one of the days.

And like, I’ve kind of come off of powerlifting.

HANNAH: Okay.

JANNINE:

So it’s more like I’ve got looking out there.

I’ve got like a Raxo and doing like squatting and deadlift and, but sure.

It’s super heavy and I’ve got a cable.

HANNAH: Okay.

JANNINE: If anything from 2022 till now, I’ve backed off.

HANNAH: You’ve backed off.

Okay.

JANNINE: It’s heavy, but I do have you just not as heavy.

HANNAH: Yeah.

Yeah, I would say that’s probably a good thing.

Um, um, to be honest, and it was probably what was something I was going to, you know,

recommend.

Um, sometimes we do see, you know, really.

Great athletes having some faster, uh, biological aging as well, usually causing

just maybe an overload of oxidative stress, right?

An overload of inflammation in the body too.

So I’m wondering if there’s a connection there with the musculoskeletal, but

Definitely the injury I think is why we’re seeing that musculoskeletal age

So high and I wonder how long it will take to actually get that to go down to yeah

JANNINE: Yeah, it’s definitely gonna be one of my missions. So I’m like, hmm

We will have to do a follow-up on this yeah

HANNAH: We do need to test 

JANNINE: To see what happens here because yeah, there’s there’s definitely some new things in the works for me

Actually since seeing this but also I’ve already just known I needed to change yeah

just in terms of the injury and pain and whatnot.

I think for a lot of people looking at things like this,

they may be thinking like, okay,

I have a pretty significant family history of heart disease.

I have a pretty significant family history

of different blood conditions.

It’s called blood conditions.

Not in terms of leukemia,

but more like blood conditions in terms of insulin resistance,

things of that nature.

And I’m going through perimenopause,

which is something that also really started to hit

in the last about year and a half

where I really started to have symptoms.

And so I don’t know if you’ve seen any correlations there,

anybody’s talked about it with you at all.

HANNAH: Oh yeah, yeah, definitely.

I mean, you know,

Peri menopause, going through menopause,

you’re definitely gonna accelerate

some of those biological age clocks.

It’s, it’s, that they have a,

I would say a good handful, good chunk of studies on it.

But I think they definitely need more.

I think they can have more.

But we do know that that speeds up the aging process.

So if we can delay menopause by any chance

or you know, help and reduce some of the, you know, strength of those symptoms, I would say as well.

The better you’re going to look from just an epigenetic age standpoint too. Yeah, absolutely.

JANNINE: Yeah, and I didn’t start any estrogen replacement so recently, so I’m very curious

as to what that’s going to look like too.

HANNAH: Yeah 

JANNINE:  just something I bring up for a lot of folks who

may be sitting here thinking like, oh man, everyone talks about all the estrogen receptors in the

heart and in our blood vessels like could.

HANNAH: Yeah. Yeah.

That definitely could be it.

So yeah, they’ve they’ve looked at some estrogen

supplementation to alongside of the the menopause and that can

definitely help mitigate the accelerations that were seen

within the biological age.

JANNINE: So something something to see there sounds like a cool research

study where we had like a big group of folks that are doing

these and before hormones and after.

HANNAH: Oh, I would love that.

Yeah, absolutely.

JANNINE: Really cool to see.

So, you know, overall, I’m really glad that I had the chance to do this again to really see what was going on.

And I think for a lot of people, this may be super interesting.

And we’re like, well, you know, how can I incorporate this into my regular testing kind of like alongside,

like you were mentioning the CBC, the cholesterol, things of that nature, it seems like it would go hand in hand there too,

as like we would do biannual or quarterly, you know, assessments.

HANNAH: Yeah, yeah, I see health care providers who are super successful with this are doing just that,

right, where they’re doing the traditional lab values, like maybe the genetics and the epigenetics

all at the same time, you know, set up a follow up appointment, go through all of those, start

making recommendations and, you know, educating the patient about their choices, right, what they’re

doing and how those are actually affecting the metrics and then following up by annually, you

know, you could even do it a little bit sooner, you could do it a little bit longer, depending on

on how well you think you know your body and then once you start more frequently, you can

start to wait a little bit longer to do the test in between one another. But I think that’s a

great point and something I’d absolutely recommend for anyone interested in taking the test. Really

go all in and take them all and see how everything is correlating with one another to get the best

insight and best use. 

JANNINE: Makes sense. So of course, we’ve seen some updates since the first time I

I took the test. What’s next for you guys? What are you working on? What’s,

what’s the latest and greatest that’s possible?

HANNAH: We just released a new product last week from the time we’re recording this. So it’s called

True Health. It’s basically like a vitamin antioxidant reporting panel. So we’re super excited again

about the ability for epigenetics to report out other biomarkers, right? Not just aging itself.

So we’ll see how people like the True Health Report.

I know healthcare providers and those that I’ve talked to

with it about already are starting to love it

because again, you’re able to get all of this information

with just a finger prick blood spot card.

JANNINE: Yeah, that’s huge.

I mean, that’s huge.

Sending someone to a lab, finding a mobile person

to do a draw can be a pain, but also the finger poke.

We said, once we talk some people through it, they can do it.

Cool, so with that, are we looking at

like instead of a general blood test,

like a metabolic panel,

this is very similar to a metabolic pant,

like Nutrival or something like that.

HANNAH: Yep.

JANNINE: Like give me a little background on what is close.

HANNAH: Yeah.

Yeah, you’re exactly right.

So it’s gonna be more of, you know,

that Nutraeval style.

It’s even, it’s gonna be like a Nutraeval

and like a vibrant health report combined.

So vitamin levels, amino acids,

methylation markers and antioxidants,

minerals and healthy fats.

Those are really more of like the nutritional based outcomes.

And then we even have general health markers too.

So it goes above and beyond just like a traditional nutrient.

So we’re looking at metabolic markers, immune markers, bone and mineral, hormonal,

neurocognitive, microbiome inflammation, stress markers, toxins.

So some of the PFAS, some of the forever chemicals, mitochondrial

function, oxidative stress, NAD metabolism, ketones and even supplements as well.

So quantifying all of those levels to be able to say,

“Hey, where am I deficient?

And where can I actually start to make a difference?”

Because again, epigenetics is,

it’s kind of like an HBA1C for everything, right?

Where you’re capturing more of like a three to six month

running average, which is gonna be more all inclusive

in terms of determining your health outcomes.

So we’re super excited about this panel

and people can even combine the true age

and true health tests and do it

and just want BloodSpot card too.

JANNINE: Oh, wow. Yeah. That’s huge. That’s here.

I have the all in on that. That gives us so much information.

HANNAH: Yeah. When you read tests, we’ll have to have you do the true health one too.

JANNINE: Oh, I in, sign me up. That’s right.

Amazing. Yeah.

Then I can see kind of where things are at there too.

I love it. It’s just a great way to kind of bring everything together

and all in one place and not multiple tests.

I think that’s where folks are getting a little bit with this optimization

department trying to figure out all the tests. And so this is great.

HANNAH: Oh, yeah. Absolutely. We’re super excited.

JANNINE: Well, we better tell folks where they can find you guys, how they can get

connected, get a test, or find a practitioner and go from there.

HANNAH: Yeah. If anyone’s interested, just try it. I promise you, you’ll, you’ll

like it. It’s tru diagnostic.com. T. R. U. diagnostic is singular.

If you have any questions or you need to find a practitioner and just reach

out to support@trudiagnostic.com.

And I have my Everything Epigenetics channel too.

If anyone’s ever interested in learning a little bit more about epigenetics.

JANNINE: Awesome.

Yes, that’s fun.

I have tuned in before and learned all the thoughts.

So guys, if you’re geeking out here and you’re enjoying this, go check Hannah

out over there and everything epigenetics and no doubt you will be blown away.

Thank you again for coming on.

I sincerely appreciate it and for letting me do another test and being able to

update myself and everybody here as to what’s going on with me and how we can use me as a tool to help everybody else.

HANNAH: Awesome. Thanks, Dr. Krause.

[Outro] Hey, fellow health junkie. Thanks for listening to the Health Fix Podcast.

If you enjoyed tuning in, please help support me to get the word out about the podcast.

Subscribe, rate, and review and just get that word out. Thanks again for listening.

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