Did you know that the food can communicate with your cells? The foods we ingest have microRNAs, small cellular pieces that can interfere with messages from our cells to create proteins involved in cell aging, tumor formation, tumor suppression, bone growth and more. MicroRNAs have been researched for over 20 years and thousands of them have been identified in that time. While research in the realm of microRNAs has been heavily focused on cancer we are now starting to see data on how our lifestyle choices, exercise, physical fitness and the type of diet we consume directly affect microRNA levels in our body. In this episode Doc J breaks down why microRNAs may be a way to assess the impact of your diet and lifestyle on your overall health and what diet and lifestyle interventions seem to make the most impact on overall health.

What You’ll Learn In Today’s Episode:

• How herbs and veggies protect us from cancer
• Why diets excluding entire food groups may not benefit us
• How microRNA might be a novel way to measure health status
• How alcohol consumption and physical fitness affect microRNA

Resources From This Episode:
• BMC Genomics. 2017; 18(Suppl 2): 112.
Published online 2017 Mar 14. doi: 10.1186/s12864-017-3502-3
PMCID: PMC5374554
• Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
Yu-Chen Liu,1 Wen Liang Chen,2 Wei-Hsiang Kung,1 and Hsien-Da Huang 1,2,3,4

• MicroRNA Function in Human Diseases – Natarajan S.K. · Smith M.A. · Wehrkamp C.J. · Mohr A.M. · Mott J.L.
• Med Epigenet 2013;1:106-115
• Methods Mol Biol. 2017;1617:225-239. doi: 10.1007/978-1-4939-7046-9_17.

• MiR-92a – At the Heart of Lipid-Driven Endothelial Dysfunction
• Menno P.J. de Winther, Esther Lutgens
• https://doi.org/10.1161/CIRCRESAHA.114.303125
• Circulation Research. 2014;114:399-401
• Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet.
• Shah MS, Schwartz SL, Zhao C, Davidson LA, Zhou B, Lupton JR, Ivanov I, Chapkin RS
• Physiol Genomics. 2011 May 1; 43(10):640-54.
• MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice.
• Padi SK, Zhang Q, Rustum YM, Morrison C, Guo B
• Gastroenterology. 2013 Aug; 145(2):437-46.
• MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
• Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH
• Mol Nutr Food Res. 2012 Aug; 56(8):1259-69.
• Dietary walnut suppression of colorectal cancer in mice: Mediation by miRNA patterns and fatty acid incorporation.
• Tsoukas MA, Ko BJ, Witte TR, Dincer F, Hardman WE, Mantzoros CS
• J Nutr Biochem. 2015 Jul; 26(7):776-83.

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